Article

Journal of Tongji Medical University

, Volume 21, Issue 4, pp 321-322

First online:

Study on the changes in microvessel density in hepatocellular carcinoma following transcatheter arterial chemoembolization

  • Yi JilinAffiliated withDepartment of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Liao XiaofengAffiliated withDepartment of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Yang ZhifangAffiliated withDepartment of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • , Li XingruiAffiliated withDepartment of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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Summary

To study the changes in intratumoral microvessel density (MVD) in hepatocellular carcinoma (HCC) following transcatheter arterial chemoembolization (TACE), MVD in 42 HCC specimens histologically verified was studied by using immunohistochemical method. Of all the specimens, 20 were obtained from the patients treated with surgical resection alone, 22 from those with second stage surgical resection after TACE. The results showed that the MVD in HCC tissues was 53. 4±21. 9 in the TACE group and 27. 6±9. 2 in the single operating group, respectively, with the difference being significant between them (P<0. 001). It was suggested that TACE might contribute to angiogenesis of HCC, possibly due to anoxic stress and ischemia-reperfusion injury.

Key words

hepatocellular carcinoma chemoembolization therapeutic microvessel density