Article

Indian Journal of Clinical Biochemistry

, Volume 20, Issue 2, pp 192-194

Iron store and free radicals in thalassemia

  • K. GoswamiAffiliated withDept of Biochemistry, Vivekananda Institute of Medical Sciences Email author 
  • , S. GhoshAffiliated withDept of Biochemistry, Vivekananda Institute of Medical Sciences
  • , M. BandyopadhyayAffiliated withDept of Biochemistry, Vivekananda Institute of Medical Sciences
  • , K. L. MukherjeeAffiliated withDept of Biochemistry, Vivekananda Institute of Medical Sciences

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Abstract

Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload.

Key words

Thalassemia Ferritin Malondialdehyde