Indian Journal of Clinical Biochemistry

, Volume 18, Issue 2, pp 150–153

Reversible suppression of nitric oxide system in essential hypertension

  • M. Chandra
  • D. R. Maurya
  • S. Kumar
  • H. Basara
  • A. Ghatak
  • B. L. Tekwani
  • G. Kaur
  • M. K. Misra
Article

DOI: 10.1007/BF02867381

Cite this article as:
Chandra, M., Maurya, D.R., Kumar, S. et al. Indian J Clin Biochem (2003) 18: 150. doi:10.1007/BF02867381

Abstract

Despite enormous research in the field of hypertension, its pathophysiology still remains largely unresolved and appears to be multifactorial. In the present communication, we have analyzed the status of nitric oxide (NO) in the patients with essential hypertension and age matched controls. We have found that the levels of NO are lowered in essential hypertension. The normalization of blood pressure by administration of antihypertensive therapy causes rise in the NO level indicating that perturbed NO status in essential hypertension is reversible. Addition of antioxidant to the antihypertensive drugs causes a further, though non significant, rise in the levels of NO, suggesting that antioxidants may be combined with antihypertensive drugs as adjunct in the management of essential hypertension.

Key words

Nitric oxideEssential hypertensionAntihypertensive treatmentAntioxidants

Copyright information

© Association of Clinical Biochemists of India 2003

Authors and Affiliations

  • M. Chandra
    • 1
  • D. R. Maurya
    • 1
  • S. Kumar
    • 1
  • H. Basara
    • 1
  • A. Ghatak
    • 2
  • B. L. Tekwani
    • 3
  • G. Kaur
    • 4
  • M. K. Misra
    • 4
  1. 1.ICU, Department of Medicine, King George's Medical CollegeLucknow UniversityLucknowIndia
  2. 2.Division of Clinical Experimental MedicineLucknow UniversityLucknowIndia
  3. 3.Division of Biochemistry, Central Drug Research InstituteLucknow UniversityLucknowIndia
  4. 4.Department of BiochemistryUniversity of LucknowLucknowIndia