Summary
The anti-endotoxic effect of syringic acid (SA) isolated fromRadix Isatidis (Banlangen, BLG) was studied. SA was extracted and isolated from BLG and diluted into 1% solution. The content of SA-pretreated endotoxin (ET) was quantitatively determined using Limulus test. The ability of fever induction of ET pretreated with SA was measured using endotoxin-induced fever test in rabbits. The LPS-induced death in mice pretreated with and without SA was compared. Results showed that after pretreatment with SA, 83.16% of ET was destroyed, the ET-induced fever in rabbits relieved markedly and the LPS-induced death rate in mice dropped from 68 % to 20 %. It was concluded that SA isolated from BLG had anti-endotoxic effects.
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References
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LIU Yunhai, male, born in 1942, Pharmacist
This project was supported by a grant from National Natural Sciences Foundation (No. 39870872) and Foundation of Public Healthy Ministry of China (No. 98-2-110).
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Yunhai, L., Jianguo, F., Ting, L. et al. Anti-endotoxic effects of syringic acid ofRadix Isatidis. Current Medical Science 23, 206–208 (2003). https://doi.org/10.1007/BF02859960
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DOI: https://doi.org/10.1007/BF02859960