Archives of Pharmacal Research

, 11:127

The crystal structure of fenbufen, 3-(4-biphenylylcarbonyl)propionic acid (C16H14O3), a non-steroidal antiinflammatory agent

Authors

  • Yang Bae Kim
    • College of PharmacySeoul National University
  • Il Yeong Park
    • College of PharmacySeoul National University
  • Yang Hwan Park
    • College of PharmacySeoul National University
Original Articles

DOI: 10.1007/BF02857715

Cite this article as:
Kim, Y.B., Park, I.Y. & Park, Y.H. Arch. Pharm. Res. (1988) 11: 127. doi:10.1007/BF02857715

Abstract

The crystal structure of fenbufen was determined by X-ray diffraction techniques. The compound was recrystallized in orthorhombic crystal system, space groupPca21,a=31.918(10),b=5.550(2),c=15.078(9) Å,Dm=1.26,Dx=1.264 g/cm3, andZ=8. The structure was solved by direct methods and refined by least-squares procedure to the finalR value of 0.051 for 1780 independent reflections. Two molecules in the asymmetric unit are related by a pseudo center of symmetry and dimerizedvia O−H…O hydrogen bonds. The carbonyl group attached to the phenyl ring is nearly coplanar to the ring. In the crystal the molecules are arranged in parallel stacks in thea direction.

Key words

non-steroidal antiinflammatory agentfenbufenX-ray diffraction
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Copyright information

© The Pharmaceutical Society of Korea 1988