The AAPS Journal

, Volume 8, Issue 2, pp E239–E253

Drug discovery from natural sources

Authors

  • Young-Won Chin
    • Division of Medicinal Chemistry and Pharmacognosy, College of PharmacyThe Ohio State University
  • Marcy J. Balunas
    • Division of Medicinal Chemistry and Pharmacognosy, College of PharmacyThe Ohio State University
    • Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyUniversity of Illinois at Chicago
  • Hee Byung Chai
    • Division of Medicinal Chemistry and Pharmacognosy, College of PharmacyThe Ohio State University
    • Division of Medicinal Chemistry and Pharmacognosy, College of PharmacyThe Ohio State University
Article

DOI: 10.1007/BF02854894

Cite this article as:
Chin, Y., Balunas, M.J., Chai, H.B. et al. AAPS J (2006) 8: E239. doi:10.1007/BF02854894

Abstract

Organic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Over 20 new drugs launched on the market between 2000 and 2005, originating from terrestrial plants, terrestrial microorganisms, marine organisms, and terrestrial vertebrates and invertebrates, are described. These approved substances, representative of very wide chemical diversity, together with several other natural products or their analogs undergoing clinical trials, continue to demonstrate the importance of compounds from natural sources in modern drug discovery efforts.

Keywords

natural productsdrug discoveryterrestrial plantsterrestrial microorganismsmarine organismsterrestrial vertebratesterrestrial invertebrateschemical diversity

Copyright information

© American Association of Pharmaceutical Scientists 2006