Advances in Therapy

, Volume 19, Issue 1, pp 17-26

First online:

Selective serotonin reuptake inhibitor discontinuation syndrome: A review

  • Lut TamamAffiliated withDepartment of Psychiatry, Cukurova University Faculty of Medicine
  • , Nurgul OzpoyrazAffiliated withDepartment of Psychiatry, Cukurova University Faculty of Medicine

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed in the treatment of depression and anxiety, as well as obsessive-compulsive, eating, and impulse-control disorders. Paralleling their widespread use has been an increase in adverse-effect reports not noted during short-term efficacy studies. Significant among these adverse effects is SSRI discontinuation syndrome, which follows the interruption of extended treatment or a reduction in drug dosage and entails somatic and psychological symptoms. These self-limiting symptoms resolve on reintroduction of the drug and cannot be explained as a remanifestation of the original disorder. To facilitate proper diagnosis and avoid unnecessary therapeutic or diagnostic interventions, all physicians who prescribe SSRIs should become familiar with these symptoms. The most appropriate approach to therapy for discontinuation syndrome involves educating patients and reassuring them that this is a reversible condition, reinstating the original SSRI, and further slowing the rate of tapering.


selective serotonin reuptake inhibitors antidepressants discontinuation syndrome adverse effects