Abstract
Hyperbaric oxygen (HBO) therapy has been used to treat patients with numerous disorders, including stroke. This treatment has been shown to decrease cerebral edema, normalize water content in the brain, decrease the severity of brain infarction, and maintain blood-brain barrier integrity. In addition, HBO therapy attenuates motor deficits, decreases the risks of sequelae, and prevents recurrent cerebral circulatory disorders, thereby leading to improved outcomes and survival. Hyperbaric oxygen also accelerates the regression of atherosclerotic lesions, promotes antioxidant defenses, and suppresses the proliferation of macrophages and foam cells in atherosclerotic lesions. Although no medical treatment is available for patients with cerebral palsy, in some studies, HBO therapy has improved the function of damaged cells, attenuated the effects of hypoxia on the neonatal brain, enhanced gross motor function and fine motor control, and alleviated spasticity. In the treatment of patients with migraine, HBO therapy has been shown to reduce intracranial pressure significantly and abort acute attacks of migraine, reduce migraine headache pain, and prevent cluster headache. In studies that investigated the effects of HBO therapy on the damaged brain, the treatment was found to inhibit neuronal death, arrest the progression of radiation-induced neurologic necrosis, improve blood flow in regions affected by chronic neurologic disease as well as aerobic metabolism in brain injury, and accelerate the resolution of clinical symptoms. Hyperbaric oxygen has also been reported to accelerate neurologic recovery after spinal cord injury by ameliorating mitochondrial dysfunction in the motor cortex and spinal cord, arresting the spread of hemorrhage, reversing hypoxia, and reducing edema. HBO has enhanced wound healing in patients with chronic osteomyelitis. The results of HBO therapy in the treatment of patients with stroke, atherosclerosis, cerebral palsy, intracranial pressure, headache, and brain and spinal cord injury are promising and warrant further investigation.
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Plafki C, Peters P, Almeling M, Welslau W, Busch R. Complications and side effects of hyperbaric oxygen therapy.Aviat Space Environ Med. 2000;71:119–124.
Al-Waili N, Butler G, Beale J, Hamilton R, Lee B, Lucas P. Hyperbaric oxygen and malignancies: a potential role in radiotherapy, chemotherapy, tumor surgery and phototherapy.Med Sci Monit. 2005;11:279–289.
Roeckl-Wiedmann I, Bennett M, Kranke P. Systematic review of hyperbaric oxygen in the management of chronic wounds.Br J Surg. 2005;92:24–32.
Abdullah MS, Al-Waili NS, Butler G, Baban NK. Hyperbaric oxygen as an adjunctive therapy for bilateral compartment syndrome, rhabdomyolysis and acute renal failure after heroin intake.Arch Med Res. In press.
Boerema I, Meyne NG, Brummelkamp WK, et al. Life without blood: a study of the influence of high atmospheric pressure and hypothermia on dilution of blood.J Cardiovasc Surg (Torino). 1960;1:133–146.
Sukoff MH, Ragatz RE. Hyperbaric oxygenation for the treatment of acute cerebral edema.Neurosurgery. 1982;10:29–38.
Mink RB, Dutka AJ. Hyperbaric oxygen after global cerebral ischemia in rabbits does not promote brain lipid peroxidation.Crit Care Med. 1995;23:1398–1404.
Thom SR. Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats.Toxicol Appl Pharmacol. 1993;123:248–256.
Mink RB, Dutka AJ. Hyperbaric oxygen after global cerebral ischemia in rabbits reduces brain vascular permeability and blood flow.Stroke. 1995;26:2307–2312.
Weinstein PR, Hameroff SR, Johnson PC, Anderson GG. Effect of hyperbaric oxygen therapy or dimethyl sulfoxide on cerebral ischemia in unanesthetized gerbils.Neurosurgery. 1986;18: 528–532.
Sunami K, Takeda Y, Hashimoto M, Hirakawa M. Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery.Crit Care Med. 2000;28:2831–2836.
Burt JT, Kapp JP, Smith RR. Hyperbaric oxygen and cerebral infarction in the gerbil.Surg Neurol. 1987;28:265–268.
Wassmann H. Stroke therapy. Combined therapy of hyperbaric oxygenation and extra-intracranial arterial bypass operation.Fortschr Med. 1982;100:285–288.
Elinskii MP, Rafikov AM, Ivanova NE, Kesaev SA. Therapeutic use of hyperbaric oxygenation in ischemic strokes.Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84:1321–1325.
Titovets E, Nechipurenko N, Griboedova T, Vlasyuk P. Experimental study on brain oxygenation in relation to tissue water redistribution and brain oedema.Acta Neurochir Suppl. 2000;76:279–281.
Chang CF, Niu KC, Hoffer BJ, Wang Y, Borlongan CV. Hyperbaric oxygen therapy for treatment of postischemic stroke in adult rats.Exp Neurol. 2000;166:298–306.
Mink RB, Dutka AJ. Hyperbaric oxygen after global cerebral ischemia in rabbits reduces brain vascular permeability and blood flow.Stroke. 1995;26:2307–2312.
Krakovsky M, Rogatsky G, Zarchin N, Mayevsky A. Effect of hyperbaric oxygen therapy on survival after global cerebral ischemia in rats.Surg Neurol. 1998;49:412–416.
Schabitz WR, Schade H, Heiland S, et al. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI.Stroke. 2004;35:1175–1179.
Yin D, Zhou C, Kusaka I, et al. Inhibition of apoptosis by hyperbaric oxygen in a rat focal cerebral ischemic model.J Cereb Blood Flow Metab. 2003;23:855–864.
Miljkovic-Lolic M, Silbergleit R, Fiskum G, Rosenthal RE. Neuroprotective effects of hyperbaric oxygen treatment in experimental focal cerebral ischemia are associated with reduced brain leukocyte myeloperoxidase activity.Brain Res. 2003;971:90–94.
Lou M, Eschenfelder CC, Herdegen T, Brecht S, Deuschl G. Therapeutic window for use of hyperbaric oxygenation in focal transient ischemia in rats.Stroke. 2004;35:578–583.
Calvert JW, Yin W, Patel M, et al. Hyperbaric oxygenation prevented brain injury induced by hypoxia-ischemia in a neonatal rat model.Brain Res. 2002;951:1–8.
Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke.Neurology. 2002;58:945–952.
Yin W, Badr AE, Mychaskiw G, Zhang JH. Downregulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model.Brain Res. 2002;926:165–171.
Atochin DN, Fisher D, Thom SR, Demchenko IT. Hyperbaric oxygen inhibits neutrophil infiltration and reduces postischemic brain injury in rats.Ross Fiziol Zh Im I M Sechenova. 2001;87:1118–1125.
Veltkamp R, Warner DS, Domoki F, Brinkhous AD, Toole JF, Busija DW. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats.Brain Res. 2000;853:68–73.
Ostrowski RP, Colohan AR, Zhang JH. Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage.J Cereb Blood Flow Metab. 2005;25:554–571.
Neubauer RA, End E. Hyperbaric oxygenation as an adjunct therapy in strokes due to thrombosis: a review of 122 patients.Stroke. 1980;11:297–300.
Kapp JP. Neurological response to hyperbaric oxygen—a criterion for cerebral revascularization.Surg Neurol. 1981;15:43–46.
Lebedev VV, Isakov IV, Pravdenkova SV. Effect of hyperbaric oxygenation on the clinical course and complications of the acute period of ischemic stroke.Zh Vopr Neirokhir Im N N Burdenko. 1983; 3:37–42.
Pravdenkova SV, Romasenko MV, Shelkovskii VN. Hyperbaric oxygenation and prevention of recurrent cerebral circulatory disorders in the acute stage of a stroke.Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84:1147–1151.
Shchukovskii VV, Zhdanov GG, Voskresenskaia ON, Kosiagina OL, Belov OV. Effects of hyperoxia regimes on the state of lipid peroxidation and hemostasis in patients with lesions of the central nervous system.Anesteziol Reanimatol. 1994;5:52–55.
Roman GC. Hyperbaric oxygenation: a promising treatment for Binswanger’s disease.Rev Neurol. 1999;28:707–713.
Lim J, Lim WK, Yeo TT, Sitoh YY, Low E. Management of haemorrhagic stroke with hyperbaric oxygen therapy—a case report.Singapore Med J. 2001;42:220–223.
Nighoghossian N, Trouillas P. Hyperbaric oxygen in the treatment of acute ischemic stroke: an unsettled issue.J Neurol Sci. 1997;150:27–31.
Nighoghossian N, Trouillas P, Adeleine P, Salord F. Hyperbaric oxygen in the treatment of acute ischemic stroke: a double-blind pilot study.Stroke. 1995;26:1369–1372.
Alternative Therapy Evaluation Committee for the Insurance Corporation of British Columbia. A review of the scientific evidence on the treatment of traumatic brain injuries and strokes with hyperbaric oxygen.Brain Inj. 2003;17:225–236.
Rogatsky GG, Shifrin EG, Mayevsky A. Optimal dosing as a necessary condition for the efficacy of hyperbaric oxygen therapy in acute ischemic stroke: a critical review.Neurol Res. 2003;25:95–98.
Simanonok JP. Non-ischemic hypoxia of the arterial wall is a primary cause of atherosclerosis.Med Hypotheses. 1996;46:155–161.
Haugaard N. Cellular mechanisms of oxygen toxicity.Physiol Rev. 1968;48:311–373.
Dennery PA, Spitz DR, Yang G, et al. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.J Clin Invest. 1998;101:1001–1011.
Padgaonkar VA, Giblin FJ, Fowler K, Leverenz VR, Reddan JR, Dziedzic DC. Heme oxygenase synthesis is induced in cultured lens epithelium by hyperbaric oxygen or puromycin.Exp Eye Res. 1997;65:435–443.
Ishikawa K, Navab M, Leitinger N, Fogelman AM, Lusis AJ. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.J Clin Invest. 1997;100: 1209–1216.
Ishikawa K, Poss KD, Navab M, Fogelman AM, Tonegawa S, Lusis AJ. Vasculitis, atherosclerosis and altered high density lipoproteins in heme oxygenase-1 knockout mice.Circulation. 1999; 98(suppl I):I-309.
Harabin AL, Braisted JC, Flynn ET. Response of antioxidant enzymes to intermittent and continuous hyperbaric oxygen.J Appl Physiol. 1990;69:328–335.
Kudchodkar BJ, Wilson J, Lacko A, Dory L. Hyperbaric oxygen reduces the progression and accelerates the regression of atherosclerosis in rabbits.Arterioscler Thromb Vasc Biol. 2000;20: 1637–1643.
Reut NI, Kononova TI. Outpatient electromagnetic therapy combined with hyperbaric oxygenation in arterial occlusive diseases.Khirurgiia (Mosk). 1990;11:41–43.
Kuyama T, Umemura H, Sudo T, et al. Clinical studies on various therapies for the intractable trauma of toes and fingers in cases of diabetes mellitus and peripheral ischemic diseases.Nippon Geka Gakkai Zasshi. 1988;89:763–770.
Belov KV, Aliab’ev VS, Shishkin EK. Results of the conservative treatment of patients with ischemia of the lower extremities by hyperbaric oxygenation.Vestn Khir Im Grek. 1987;139:43–45.
Perlman JM. Intrapartum hypoxic-ischemic cerebral injury and subsequent cerebral palsy: medicolegal issues.Pediatrics. 1997;99:851–859.
Maclennan A, for the International Cerebral Palsy Task Force. A template for defining a causal relation between acute intrapartum events and cerebral palsy: International Consensus Statement.Br Med J. 1999;319:1054–1059.
Rosenbaum P. Controversial treatment of spasticity: exploring alternative therapies for motor function in children with cerebral palsy.J Child Neurol. 2003;18(suppl 1):S89-S94.
Montgomery D, Goldberg J, Amar M. Effects of hyperbaric oxygen therapy on children with spastic diplegic cerebral palsy: a pilot project.Undersea Hyperb Med. 1999;26:235–242.
Papazian O, Alfonso I. Hyperbaric oxygen treatment for children with cerebral palsy.Rev Neurol. 2003;37:359–364.
Hardy P, Collet JP, Goldberg J, et al. Neuropsychological effects of hyperbaric oxygen therapy in cerebral palsy.Dev Med Child Neurol. 2002;44:436–446.
Yatsuzuka H. Effects of hyperbaric oxygen therapy on ischemic brain injury in dogs.Masui. 1991; 40:208–223.
Kohshi K, Yokota A, Konda N, Kinoshita Y, Kajiwara H. Intracranial pressure responses during hyperbaric oxygen therapy.Neurol Med Chir (Tokyo). 1991;31:575–581.
van Hulst RA, Haitsma JJ, Klein J, Lachmann B. Oxygen tension under hyperbaric conditions in healthy pig brain.Clin Physiol Funct Imaging. 2003;23:143–148.
Beppu T, Kamada K, Yoshida Y, Arai H, Ogasawara K, Ogawa A. Change of oxygen pressure in glioblastoma tissue under various conditions.J Neurooncol. 2002;58:47–52.
Ren H, Wang W, Ge Z, Zhang J. Clinical, brain electric earth map, endothelin and transcranial ultrasonic Doppler findings after hyperbaric oxygen treatment for severe brain injury.Chin Med J (Engl). 2001;114:387–390.
Rockswold G, Ford S, Anderson D, Bergman T, Sherman R. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen.J Neurosurg. 1992; 27:687–688.
Jiang J, Tysseborn I. Cerebrospinal fluid pressure changes after acute carbon monoxide poisoning and therapeutic effects of normobaric and hyperbaric oxygen in conscious rats.Undersea Hyperb Med. 1997;24:245–254.
Luongo C, Mignini R, Vicario C, Sammartino A. Hyperbaric oxygen therapy in the treatment of benign intracranial hypertension. Follow-up of a preliminary study.Minerva Anestesiol. 1992;58(4 suppl 1):97–98.
Sukoff MH, Ragatz RE. Hyperbaric oxygenation for the treatment of acute cerebral edema.Neurosurgery. 1982;10:29–38.
Rockswold GL, Ford SE, Anderson DC, Bergman TA, Sherman RE. Results of a prospective randomized trial for treatment of severely brain-injured patients with hyperbaric oxygen.J Neurosurg. 1992;76:929–934.
Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.J Neurosurg. 2001;94:403–411.
Pascual J. New perspectives in migraine treatment: how to treat the difficult migraine patient.Neurologia. 2004;19(suppl 2):1–7.
Loder E. Fixed drug combinations for the acute treatment of migraine: place in therapy.CNS Drugs. 2005;19:769–784.
Saloom K, Al-Waili N. Salicylate to treat acute migraine attacks: double-blind placebo controlled study (abstract).FASEB J. 2001;15:A560.
Ekbom K. Treatment of cluster headache: clinical trials, design and results.Cephalalgia. 1995; 15(suppl 15):33–36.
Stovner LJ, Sjaastad O. Treatment of cluster headache and its variants.Curr Opin Neurol. 1995; 8:243–247.
Weiss LD, Ramasastry SS, Eidelman BH. Treatment of a cluster headache patient in a hyperbaric chamber.Headache. 1989;29:109–110.
Nilsson Remahl AI, Ansjon R, Lind F, Waldenlind E. Hyperbaric oxygen treatment of active cluster headache: a double-blind placebo-controlled cross-over study.Cephalalgia. 2002;22:730–739.
Wilson JR, Foresman BH, Gamber RG, Wright T. Hyperbaric oxygen in the treatment of migraine with aura.Headache. 1998;38:112–115.
Myers DE, Myers RA. A preliminary report on hyperbaric oxygen in the relief of migraine headache.Headache. 1995;35:197–199.
Di Sabato F, Rocco M, Martelletti P, Giacovazzo M. Hyperbaric oxygen in chronic cluster headaches: influence on serotonergic pathways.Undersea Hyperb Med. 1997;24:117–122.
Pascual J, Peralta G, Sanchez U. Preventive effects of hyperbaric oxygen in cluster headache.Headache. 1995;35:260–261.
Di Sabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache.Pain. 1993;52:243–245.
Di Sabato F, Giacovazzo M, Cristalli G, Rocco M, Fusco BM. Effect of hyperbaric oxygen on the immunoreactivity to substance P in the nasal mucosa of cluster headache patients.Headache. 1996;36:221–223.
Rosenthal RE, Silbergleit R, Hof PR, Haywood Y, Fiskum G. Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest.Stroke. 2003;34:1311–1316.
Palzur E, Vlodavsky E, Mulla H, Arieli R, Feinsod M, Soustiel JF. Hyperbaric oxygen therapy for reduction of secondary brain damage in head injury: an animal model of brain contusion.J Neurotrauma. 2004;21:41–48.
Nida TY, Biros MH, Pheley AM, Bergman TA, Rockswold GL. Effect of hypoxia or hyperbaric oxygen on cerebral edema following moderate fluid percussion or cortical impact injury in rats.J Neurotrauma. 1995;12:77–85.
McDonagh M, Helfand M, Carson S, Russman BS. Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the evidence.Arch Phys Med Rehabil. 2004;85:1198–1204.
Chuba PJ, Aronin P, Bhambhani K, et al. Hyperbaric oxygen therapy for radiation-induced brain injury in children.Cancer. 1997;80:2005–2012.
Golden ZL, Neubauer R, Golden CJ, Greene L, Marsh J, Mleko A. Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen therapy.Int J Neurosci. 2002;112: 119–131.
Shi XY, Tang ZQ, Xiong B, et al. Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.Chin J Traumatol. 2003;6:346–349.
Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.J Neurosurg. 2001;94:403–411.
Cordoba-Cabeza T, Perez-Fonseca R, Morales-Vargas D, Lopez A. Hyperbaric oxygenation and neurological recovery in children with organic brain damage.Rev Neurol. 1998;27:571–574.
Livshits BM. The effect of hyperbaric oxygenation on the manifestation of brain edema at different periods of an acute experimental compression-dislocation syndrome.Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93:61–63.
Isakov IuV, Romasenko MV. Effect of hyperbaric oxygenation on total water content of brain tissue in experimental traumatic edema of the brain.Zh Vopr Neirokhir Im N N Burdenko. 1986; 1:25–27.
Artru F, Chacornac R, Deleuze R. Hyperbaric oxygenation for severe head injuries: preliminary results of a controlled study.Eur Neurol. 1976;14:310–318.
Isakov IuV, Anan’ev GV, Romasensko MV, Aide KhB. Hyperbaric oxygenation in the acute period of craniocerebral injuries.Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82:7–12.
Huang L, Mehta MP, Eichhorn JH, Nanda A, Zhang JH. Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats.Acta Neurochir Suppl. 2003; 86:433–438.
Huang L, Mehta MP, Nanda A, Zhang JH. The role of multiple hyperbaric oxygenation in expanding therapeutic windows after acute spinal cord injury in rats.J Neurosurg Spine. 2003;99:198–205.
Dave KR, Prado R, Busto R, et al. Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in Wobbler mice.Neuroscience. 2003;120: 113–120.
Buhlmann AA. Decompression sickness of the spinal cord: results of early and of late treatment.Schweiz Med Wochenschr. 1985;115:796–800.
Kutlay M, Colak A, Demircan N, et al. Effect of hyperbaric oxygen therapy on fetal spinal grafts: an experimental study.Undersea Hyperb Med. 2000;27:205–213.
Murakami N, Horinouchi T, Sakurai M, et al. Hyperbaric oxygen therapy given 30 minutes after spinal cord ischemia attenuates selective motor neuron death in rabbits.Crit Care Med. 2001;29:814–818.
Yeo JD, Stabback S, McKenzie B. A study of the effects of hyperbaric oxygen on the experimental spinal cord injury.Med J Aust. 1977;2:145–147.
Yeo JD, McKenzie B, Hindwood B, Kidman A. Treatment of paraplegic sheep with hyperbaric oxygen.Med J Aust. 1976;1:538–540.
Elinskii MP, Rafikov AM, Baibus GN. Therapeutic use of hyperbaric oxygenation in lesions of the spinal cord.Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84:682–687.
Asamoto S, Sugiyama H, Doi H, Iida M, Nagao T, Matsumoto K. Hyperbaric oxygen (HBO) therapy for acute traumatic cervical spinal cord injury.Spinal Cord. 2000;38:538–540.
Ishihara H, Matsui H, Kitagawa H, Yonezawa T, Tsuji H. Prediction of the surgical outcome for the treatment of cervical myelopathy by using hyperbaric oxygen therapy.Spinal Cord. 1997;35: 763–767.
Sakakibara R, Hattori T, Tojo M, Yamanishi T, Yasuda K, Hirayama K. Micturitional disturbance in radiation myelopathy.J Spinal Disord. 1993;6:402–405.
Narayana PA, Kudrle WA, Liu SJ, Charnov JH, Butler BD, Harris JH Jr. Magnetic resonance imaging of hyperbaric oxygen treated rats with spinal cord injury: preliminary studies.Magn Reson Imaging. 1991;9:423–428.
Neretin V, Lobov MA, Kiselev SO, Lagutina TS, Kiriakov VA. Effect of hyperbaric oxygenation on the recovery of motor functions in vertebrogenic myelopathies.Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85:1774–1778.
Eltorai I, Hart GB, Strauss MB. Osteomyelitis in the spinal cord injured: a review and a preliminary report on the use of hyperbaric oxygen therapy.Paraplegia. 1984;22:17–24.
Yeo JD. The use of hyperbaric oxygen to modify the effects of recent contusion injury to the spinal cord.Cent Nerv Syst Trauma. 1984;1:161–165.
Higgins AC, Pearlstein RD, Mullen JB, Nashold BS Jr. Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury.J Neurosurg. 1981;55: 501–510.
Holbach KH, Wassmann H, Linke D. The use of hyperbaric oxygenation in the treatment of spinal cord lesions.Eur Neurol. 1977;16:213–221.
Gamache FW Jr, Myers RA, Ducker TB, Cowley RA. The clinical application of hyperbaric oxygen therapy in spinal cord injury: a preliminary report.Surg Neurol. 1981;15:85–87.
Prockop LD, Grasso RJ. Ameliorating effects of hyperbaric oxygenation on experimental allergic encephalomyelitis.Brain Res Bull. 1978;3:221–225.
Yeo JD, Lowry C, McKenzie B. Preliminary report on ten patients with spinal cord injuries treated with hyperbaric oxygen.Med J Aust. 1978;2:572–573.
Barratt DM, Harch PG, Van Meter K. Decompression illness in divers: a review of the literature.Neurologist. 2002;8:186–202.
Yildiz S, Kiralp MZ, Akin A, et al. A new treatment modality for fibromyalgia syndrome: hyperbaric oxygen therapy.Int Med Res. 2004;32:263–267.
Germain G, Delaney J, Moore G, Lee P, Lacroix V, Montgomery D. Effect of hyperbaric oxygen therapy on exercise-induced muscle soreness.Undersea Hyperb Med. 2003;30:135–145.
Kiralp MZ, Yildiz S, Vural D, Keskin I, Ay H, Dursun H. Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome.J Int Med Res. 2004;32:258–262.
Tuter NV, Danilov AB, Poliakova LV. The treatment of a complex regional pain syndrome.Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97:33–35.
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Al-Waili, N.S., Butler, G.J., Beale, J. et al. Hyperbaric oxygen in the treatment of patients with cerebral stroke, brain trauma, and neurologic disease. Adv Therapy 22, 659–678 (2005). https://doi.org/10.1007/BF02849960
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DOI: https://doi.org/10.1007/BF02849960