Advances in Therapy

, Volume 22, Issue 6, pp 527–542

Effects of fluvastatin slow-release (xl 80 mg) versus simvastatin (20 mg) on the lipid triad in patients with type 2 diabetes

  • Maurizio Bevilacqua
  • Velella Righini
  • Massimo Barrella
  • Tarcisio Vago
  • Enrica Chebat
  • Ligia J. Dominguez
Article

DOI: 10.1007/BF02849947

Cite this article as:
Bevilacqua, M., Righini, V., Barrella, M. et al. Adv Therapy (2005) 22: 527. doi:10.1007/BF02849947

Abstract

The lipid triad is the association of small, dense (sd) low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and hypertriglyceridemia, all of which play a role in coronary artery disease in patients with type 2 diabetes. Although statins have demonstrated clear positive effects on cardiovascular morbidity/mortality in patients with diabetes and on single components of the lipid triad, it remains controversial whether they affect all components of the triad in these patients. Therefore, we performed a single-center, parallel-group, prospective, randomized, open-label, blinded-endpoint (PROBE)-type comparison of fluvastatin extended-release (XL) 80 mg (n=48) and simvastatin 20 mg (n=46), each given once daily for 2 months to patients with type 2 diabetes with the lipid triad, who were enrolled after a 1-month lifestyle modification and dietary intervention program. After fluvastatin therapy, LDL (-51%; P > .01), apolipoprotein B (ApoB;-33%; P > .01, intermediate-density LDL (idLDL) (-14.3%; P > .05), sdLDL (-45%; P > .01), and triglycerides (-38%; P > .01) were significantly decreased, and HDL (+14.3%; P > .05) and apolipoprotein A-I (ApoA-I; +7%; P > .05) were increased; large buoyant (lb) LDL did not change (P=NS). Simvastatin therapy decreased LDL (-55.1 %; P > .01), ApoB (-46%; P > .01), lbLDL (-33.3%; P > .05), idLDL (-22.7%; P > .05), sdLDL (-33.3%; P > .05), and triglycerides (-47.9%; P > .01); HDL was not changed (P=NS) after simvastatin, but ApoA-I was increased (+11.3%; P > .01). HDL increases (P > .01) and sdLDL decreases (P > .01) were significantly greater after fluvastatin compared with simvastatin therapy; LDL, triglycerides, ApoB, and idLDL changes were similar after both therapies (P=NS), and lbLDL decreases were greater with simvastatin therapy (P > .05). With both treatments, classic mean LDL and ApoB target levels were achieved in most patients. We conclude that the lipid triad can be controlled with fluvastatin XL 80 mg in patients with type 2 diabetes.

Keywords

fluvastatin XLsimvastatintype 2 diabetes mellitussmalldense LDLHDLLDLtriglyceridesApoA-IApoB

Copyright information

© Springer Science and Business Media and LLC 2005

Authors and Affiliations

  • Maurizio Bevilacqua
    • 1
  • Velella Righini
    • 1
  • Massimo Barrella
    • 1
  • Tarcisio Vago
    • 1
  • Enrica Chebat
    • 1
  • Ligia J. Dominguez
    • 2
  1. 1.Endocrinology and Diabetes Unit and LORENZ Research Center Department of MedicineLuigi Sacco Hospital (Vialba)-University of MilanMilanItaly
  2. 2.Geriatric Unit Department of Internal Medicine and GeriatricsUniversity of PalermoPalermoItaly
  3. 3.Endocrinology and Diabetes UnitLuigi Sacco Hospital (Vialba)MilanItaly