Advances in Therapy

, Volume 24, Issue 2, pp 362–367

Pregnancy-associated plasma protein-A and asthma

  • Abdurrahman Coskun
  • Oner Balbay
  • Sadik Duran
  • Ali Nihat Annakkaya
  • Ismet Bulut
  • Ozlem Yavuz
  • Emel Kurt
Article

DOI: 10.1007/BF02849905

Cite this article as:
Coskun, A., Balbay, O., Duran, S. et al. Adv Therapy (2007) 24: 362. doi:10.1007/BF02849905

Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1±5.0 mU/L) were higher than those of the control group (4.9±2.1 mU/L) (P < .01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581;P < .01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.

Keywords

asthmaatherosclerosisIGFIGFBP-4PAPP-A

Copyright information

© Springer Science and Business Media and LLC 2007

Authors and Affiliations

  • Abdurrahman Coskun
    • 1
  • Oner Balbay
    • 2
  • Sadik Duran
    • 3
  • Ali Nihat Annakkaya
    • 2
  • Ismet Bulut
    • 2
  • Ozlem Yavuz
    • 1
  • Emel Kurt
    • 2
  1. 1.Department of Clinical BiochemistryDuzce University, School of MedicineDuzceTurkey
  2. 2.Department of Pulmonary MedicineOsman Gazi University School of MedicineEskisehirTurkey
  3. 3.Department of CardiologyTurkey