The Indian Journal of Pediatrics

, Volume 66, Issue 3, pp 375–379

Evaluation of bone mineral density in children with diabetes mellitus


  • B. Ersoy
    • Department of Pediatric EndocrinologyEge University Faculty of Medicine
  • D. Gökşen
    • Division of PediatricsEge University Faculty of Medicine
  • S. Darcan
    • Department of Pediatric EndocrinologyEge University Faculty of Medicine
  • E. Mavi
    • Department of Pediatric EndocrinologyEge University Faculty of Medicine
  • C. Öztürk
    • Division of Physical Therapy and RehabilitationEge University Faculty of Medicine
Original Article

DOI: 10.1007/BF02845528

Cite this article as:
Ersoy, B., Gökşen, D., Darcan, S. et al. Indian J Pediatr (1999) 66: 375. doi:10.1007/BF02845528


Multiple studies have documented reduction in peripheral bone mass in children with insulin dependent diabetes mellitus (IDDM). In this study, the bone mineral density (BMD) of the lumbar vertebrae (L2–L4) was measured by dual photon absorptiometry in 14 female and 16 male diabetic patients of age 11 to 16 years with varying clinical duration. Twenty three children between 11 to 16 years with normal anthropometric measurements between 10th and 97th percentile and no known history of metabolic bone disease served as a control group. BMD values, weight, height, body mass index, metabolic, biochemical and growth parameters of the study group were compared with those of the control group. BMD (L2 AP 0.732±0.15 gm/cm2, L2 lateral 0.534 ±0.09 gm/cm2in the study group and 0.812±0.63 gm/cm2 and 0.619±0.20 gm/cm2 in the control group) and osteoccalcin (10.10±3.40 ng/ml and 23.12±2.74 ng/ml in diabetes and control respectively) levels were significantly lower in diabetic patients (p<0.05, p<0.01 respectively). Within the study group BMD correlated positively with age but not with the duration of the disease nor with the level of metabolic control.

Key words

Bone mineral densityInsulin dependent diabetes mellitus

Copyright information

© Dr. K C Chaudhuri Foundation 1999