Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain
Received: 12 February 1985 Accepted: 16 August 1985 DOI:
Cite this article as: Wester, P., Bateman, D.E., Dodd, P.R. et al. Neurochemical Pathology (1985) 3: 169. doi:10.1007/BF02834269 Abstract
Isolated nerve endings (synaptosomes) that show high rates of metabolic activity have been prepared up to 24 h postmortem from the brains of patients who have died suddenly. In contrast, similar preparations from brains of patients dying after a prolonged terminal illness showed little or no respiration. These data suggest that the agonal state of the patient is of major importance when investigating specific defects in neurotransmitter function in cerebral disorders and effects of neuroactive drugs on human tissue.
Index Entries Synaptosomes postmortem human brain, agonal status and metabolic activity in human brain, agonal status and metabolic activity in postmortem agonal state, and metabolic activity in postmortem human brain brain, agonal status and metabolic activity in postmortem human metabolic activity, and agonal status in postmortem human brain nerve endings, activity in postmortem human brain References
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© The Humana Press Inc. 1985