Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain
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Isolated nerve endings (synaptosomes) that show high rates of metabolic activity have been prepared up to 24 h postmortem from the brains of patients who have died suddenly. In contrast, similar preparations from brains of patients dying after a prolonged terminal illness showed little or no respiration. These data suggest that the agonal state of the patient is of major importance when investigating specific defects in neurotransmitter function in cerebral disorders and effects of neuroactive drugs on human tissue.
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- Agonal status affects the metabolic activity of nerve endings isolated from postmortem human brain
Volume 3, Issue 3 , pp 169-180
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- Humana Press
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- postmortem human brain, agonal status and metabolic activity in
- human brain, agonal status and metabolic activity in postmortem
- agonal state, and metabolic activity in postmortem human brain
- brain, agonal status and metabolic activity in postmortem human
- metabolic activity, and agonal status in postmortem human brain
- nerve endings, activity in postmortem human brain
- Author Affiliations
- 1. Department of Pathology, University of Umeå, S-90187, Umeå, Sweden
- 2. MRC Neuroendocrinology Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, England
- 3. Department of Pharmacology, University of Sydney, Sydney, Australia
- 4. Department of Biochemistry, St. Marys Hospital Medical School, London, England
- 5. Department of Pathology, Hexham General Hospital, Hexham, Northumberland, England