The Indian Journal of Pediatrics

, Volume 73, Issue 4, pp 305–309

Penicillin and gentamicin therapyvs amoxicillin/clavulanate in severe hypoxemic pneumonia

Authors

  • Arun Bansal
    • Department of Pediatrics, Advanced Pediatrics CenterPost Graduate Institute of Medical Education and Research Center
    • Department of Pediatrics, Advanced Pediatrics CenterPost Graduate Institute of Medical Education and Research Center
  • M. Jayashree
    • Department of Pediatrics, Advanced Pediatrics CenterPost Graduate Institute of Medical Education and Research Center
Original Article

DOI: 10.1007/BF02825824

Cite this article as:
Bansal, A., Singhi, S.C. & Jayashree, M. Indian J Pediatr (2006) 73: 305. doi:10.1007/BF02825824

Abstract

Objective: To compare the efficacy of sequential injectable crystalline penicillin (C.pen) and gentamicin combination followed by amoxicillin with sequential IV and oral amoxicillin-clavulanate (amox-clav) in treatment of severe or very severe hypoxemic pneumonia.Methods: Children aged 2–59 months with WHO-defined severe or very severe pneumonia with hypoxemia (SpO2<90%) were included in the study. Patients with fever>10 days, bacterial meningitis, prior antibiotic therapy >24 hours, stridor, heart disease and allergy to any of the study drugs were excluded. They were randomly allocated to two groups—Group A and Group B. Group A received C. pen and gentamicin intravenously (IV), followed by oral amoxicillin and group B got amox-clav IV, followed by oral amox-clav. Minimum duration of IV therapy was 3 days and total 7 days. Respiratory rate, oxygen saturation and chest wall indrawing were monitored 6 hourly.Results: 71 patients were included. There were two (5.2%) blood cultures positive in group A and three (9%) in group B. Organisms isolated wereS. pneumoniae (n=3) andH. influenzae-b (n=2). There was only one treatment failure in each of the groups. One was due to penicillin resistantH. influenzae-b and the other was due to worsening of pneumonia. The mean time taken for normalization of tachypnea, hypoxia, chest wall indrawing and inability to feed was similar (P-N.S). Mean duration of IV therapy in group A was 76±25 hrs and group B was 75±24 hrs (p>0.1).Conclusion: In children of 2–59 months, sequential injectable C. pen and gentamicin combination, followed by oral amoxicillin or sequential IV and oral amox-clav were equally effective for the treatment of severe or very severe hypoxemic community acquired pneumonia.

Key words

Acute respiratory infectionsCommunity acquired pneumoniaPenicillinGentamicinAmoxicillin/clavulanate

Copyright information

© Dr. K C Chaudhuri Foundation 2006