Cord blood diazepam: Clinical effects in neonates of eclamptic mothers
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Diazepam used in the treatment of eclampsia crosses the placental barrier readily, and may cause various clinical effects in the neonates. Twenty-five (25) live born babies of eclamptic mothers receiving diazepam were studied and cord blood diazepam concentration was estimated. Effect of low dose of diazepam is minimal apart from lowering of rectal temperature and the effects lasted for a period of 12 hours. But high dose (>30mg) of diazepam and prolonged duration of diazepam therapy in mothers causes significant depression of the newborn and the effects lasted for a period of 36–48 hours. As the clinical condition of the newborn is not related to the diazepam concentration in cord blood, the cord blood estimation is not helpful in the assessment of clinical effects of the drug in newborn. The tissue storage of the drug in newborn appears to be responsible for the clinical effects.
- Lean TH, Ratnam SS, Sivasamboo RR. Use of benzodiazepines in the management of eclampsia. J Obstet Gynaecol Brit Common-wealth 1968; 75: 856–862.
- Forfar JO, Arneil GC. Textbook of Pediatrics Vol. 1, 3rd edn. London: Churchill Livingstone, 1984: pp 7 and 104.
- Cree JE, Meyer J, Hailey DM. Diazepam in labour: Its metabolism and effets on the clinical condition and thermogenesis of the newborn. Br Med J 1973; 4: 251–255. CrossRef
- Gillberg C. ‘Floppy infant syndrome’ and maternal diazepam, Lancet 1977; 2: 244. CrossRef
- De Silva JAF, Schwartz MA, Stefanovic V et al. Determination of diazepam (Valium) in blood by gas liquid chromatography. Analyt Chem 1964; 36: 2099–2105. CrossRef
- De Silva JAF, Koechlin BA, Bader G. Blood level distribution patterns of diazepam and its major metabolites in man. J Pharm Sci 1966; 55: 692–702. CrossRef
- Flowers CE, Rodulph AJ, Desmond, MM. Diazepam (Valium) as an adjunct in obstetric analgesia. Obstet Gynaecol 1969; 34: 68.
- McCarthy GT, O'Connell B, Robinson AE. Blood levels of diazepam in infants of two mothers given large doses of diazepam during labour. J Obstet Gynaecol Br Commonwealth 1973; 80: 349–352.
- Owen JR, Irani SF, Blair AN. Effects of diazepam administered to mothers during labour on temperature regulation of neonate. Arch Dis Child 1972; 47: 107–110.
- Joyce DN, Kenyon VG. The use of diazepam and hydrallazine in the treatment of severe pre-eclampsia. J Obstet Gynaecol Br Commonwealth 1972; 79: 250–254.
- McAllister CB. Placental transfer and neonatal effects of diazepam when administered to women just before delivery. Br J Anaesth 1980; 52: 423–427. CrossRef
- Scher J, Hailey DM, Beard RW. Effects of diazepam on the fetus. J Obstet Gynecol Br Commonwealth, 1972; 79: 635–638.
- Gamble JAS, Moore J, Lamki H et al. A study of plasma diazepam levels in mother and infant. Br J Obstet Gynaecol 1977; 84: 588–591.
- Kanto J, Sellman R. Perinatal metabolism of diazepam. Br Med J 1974; 3: 472.
- Cord blood diazepam: Clinical effects in neonates of eclamptic mothers
The Indian Journal of Pediatrics
Volume 60, Issue 2 , pp 257-263
- Cover Date
- Print ISSN
- Online ISSN
- Springer India
- Additional Links
- Diazepam therapy
- Cord blood diazepam
- Neonatal effects
- Industry Sectors