Folia Microbiologica

, Volume 47, Issue 4, pp 375–378

Antimicrobial activity of berberine—a constituent ofMahonia aquifolium


DOI: 10.1007/BF02818693

Cite this article as:
Čerňáková, M. & Košťálová, D. Folia Microbiol (2002) 47: 375. doi:10.1007/BF02818693


The antimicrobial activity of the protoberberine, alkaloid, berberine, isolated fromMahonia aquifolium, was evaluated against 17 microorganisms including two Gram-negative bacteria—Pseudomonas aeruginosa andEscherichia coli (both resistant and sensitive), two Gram-positive bacteria—Bacillus subtilis andStaphylococcus aureus, Zoogloea ramigera, six filamentous fungi—Penicilium chrysogenum, Aspergillus niger, Aureobasidium pullulans (black and white strain),Trichoderma viride (original green strain and brown mutant),Fusarium nivale, Mycrosporum gypseum, and two yeasts—Candida, albicans andSaccharomyces cerevisiae. The IC50, minimum inhibitory concentration (MIC), minimum microbicidal concentration (MMC) and minimum microbistatic concentration (MMS) varied considerably depending on the microorganism tested, the sensitivity decreasing as follows:S. aureus >P. aeruginosa S (sensitive) >E. coli S>P. aeruginosa R (resistant) >E. coli R>B. subtilis>Z. ramigera>C. albicans>S. cerevisiae>A. pullulans B (black)>A. pullulans W (white)>T. viride Br (brown)>M. gypseum>A niger>F. nivale>P. chrysogenum>T. viride G (green).

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2002

Authors and Affiliations

  1. 1.Department of Environmental Science, Faculty of Chemical TechnologySlovak University of TechnologyBratislavaSlovakia
  2. 2.Department of Pharmacognosy and Botany, Faculty of PharmacyComenius UniversityBratislavaSlovakia