Molecular Neurobiology

, Volume 9, Issue 1, pp 253–258

Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice

Authors

  • M. L. Cordero
    • Department of PharmacologyUniversity of Puerto Rico, School of Medicine
  • J. G. Ortiz
    • Department of PharmacologyUniversity of Puerto Rico, School of Medicine
  • G. Santiago
    • Department of PharmacologyUniversity of Puerto Rico, School of Medicine
  • A. Negrón
    • Department of PharmacologyUniversity of Puerto Rico, School of Medicine
  • J. A. Moreira
    • Department of PharmacologyUniversity of Puerto Rico, School of Medicine
Article

DOI: 10.1007/BF02816124

Cite this article as:
Cordero, M.L., Ortiz, J.G., Santiago, G. et al. Mol Neurobiol (1994) 9: 253. doi:10.1007/BF02816124

Abstract

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminotransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate aminotransferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA uptake is decreased in cortex, midbrain, and pons medulla. Previous studies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SPS) mice. Glutamate Umax by System 1 is significantly decreased in these mice, whereas the Umax value for System 2 is significantly increased in the epileptic mice.

Index Entries

GlutamateGABAaudiogenic seizuresepilepsyuptakerelease

Abbreviations

GABA

gamma-aminobutyric acid

GLU

l-glutamic acid

SPS/SPS

normal mice

SPS/sps

epileptic (audiogenic seizure-susceptible) mice

NMDA

N-methyl-d-aspartate

EAA

excitatory amino acids

GAD

glutamate decarboxylase

GABA-T

GABA aminotransferase

ALA-T

alanine aminotransferase

ASP-T

aspartate aminotransferase

GDH

glutamate dehydrogenase

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© Humana Press Inc 1994