, Volume 35, Issue 1-3, pp 149-155

l-Deprenyl induces aromaticl-amino acid decarboxylase (AADC) mRNA in the rat substantia nigra and ventral tegmentum

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Abstract

l-Deprenyl is a complex drug, and number of mechanisms have been proposed to explain its effects. These include blockade of dopamine metabolism, amplification of dopamine responses, induction of superoxide dismutase or delaying apoptosis. Usingin situ hybridization techniques, we have shown thatl-deprenyl (5–10 mg/kg intraperitoneally, killed after 24 h) increases aromaticl-amino acid decarboxylase (AADC) mRNA levels in rat substantia nigraventral tegmental area. In human brain tissue, AADC is present at low levels, suggesting a possible rate-limiting role in monoamine synthesis. This is particularly important in parkinsonian patients, since the therapeutic efficacy ofl-DOPA is attributed to its enzymatic decarboxylation to dopamine. The present findings support that one of the effects ofl-deprenyl may be to facilitate the decarboxylation ofl-DOPA by increasing the availability of AADC.