In Vitro

, Volume 18, Issue 6, pp 531-537

First online:

Cholera toxin stimulation of human mammary epithelial cells in culture

  • Martha R. StampferAffiliated withPeralta Cancer Research Institute, Paralta HospitalDonner Laboratory, Lawrence Berkeley Laboratory

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Addition of cholera toxin to human mammary epithelial cultures derived from reduction mammoplasties and primary carcinomas greatly stimulated cell growth and increased the number of times the cells could be successfully subcultured. Other agents known to increase intracellular cAMP levels were also growth stimulatory. The increased growth potential conferred by cholera toxin enhances the usefulness of this cell culture system.

Key words

cholera toxin human mammary epithelial cells