Preparative regioselective acylation of glycols by enzymatic transesterification in organic solvents
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- Cesti, P., Zaks, A. & Klibanov, A.M. Appl Biochem Biotechnol (1985) 11: 401. doi:10.1007/BF02798673
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Porcine pancreatic lipase can catalyze transesterification reac tions in organic solvents in a highly regioselective manner. Lipase powder was suspended in solutions of various diols in ethyl carboxylates, and the mixtures were shaken at 30°C; as a result, pri mary monoesters of glycols were produced on a preparative scale.