Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells
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This study examined the effects of dietary (2.0 ppm for 8 wk) and in vitro (1×10−7 M) supplementation with selenium (Se, as sodium selenite) on the activity of spleen natural killer (NK) cells and plastic-adherent lymphokine-activated killer (A-LAK) cells from C57B1/6J male mice. Dietary supplementation with Se resulted in a significant increase in the lytic activity of activated NK cells, and cells from these highly lytic effector cell populations expressed significantly higher numbers of intermediate affinity interleukin-2 receptors (II-2R)/cell. In the presence of high concentrations of II-2 and 1×10−7 M Se, resting populations of spleen NK cells developed into A-LAK cells that had a significantly enhanced ability to proliferate, as indicated by the significantly higher amounts of nuclear3H-thymidine incorporation, and a significantly augmented cytolytic activity against both NK-sensitive and NK-resistant target cells. Se appears to enhance the lytic activity of activated NK cells and to augment the proliferation, expansion, and lytic activity of A-LAK cells in the presence of high concentrations of Il-2 through its ability to enhance the expression of intermediate affinity Il-2R on these cells.
- R. B. Herberman, C. W. Reynolds, and J. R. Ortaldo, Mechanism of cytotoxicity by natural killer cells,Annu. Rev. Immunol. 4, 651–680 (1985). CrossRef
- G. Trinchierl, Biology of natural killer cells,Adv. Immunol. 47, 187–376 (1989).
- N. L. Vujanovic, R. B. Herberman, A. A. Maghazachi, and J. C. Hiserodt, Lymphokine activated killer cells in rats. III. A simple method for the purification of large granular lymphocytes and their rapid expansion and conversion into lymphokine-activated killer cells,J. Exp. Med. 167, 15–29 (1988). CrossRef
- W. J. Leonard and J. P. Siegel, The interleukin-2 receptor complex and its role in the induction of nonspecific cytotoxicity, inInterleukin-2 and Killer Cells in Cancer, E. Lotzova and R. B. Herberman, eds., CRC, Boca Raton, FL, pp. 305–317 (1990).
- M. A. Beilstein, P. D. Whanger, and I. Wong, Selenium requirement and metabolism by mammalian cells in vitro, inSelenium in Biology and Medicine, Part A, G. F. Combs, J. E. Spallholz, O. H. Levander, and J. E. Oldfield, eds., Van Nostrand Reinhold, New York, pp. 197–212 (1987).
- L. Kiremidjian-Schumacher and G. Stotzky, Selenium and immune responses. A review,Environ. Res. 42, 277–303 (1987). CrossRef
- L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, and G. Stotzky, Selenium and immune cell functions: I. Effect on lymphocyte proliferation and production of interleukin-1 and interleukin-2,Proc. Soc. Exp. Biol. Med. 193, 136–142 (1990).
- M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky, Selenium and immune cell functions: II. Effect on lymphocyte-mediated cytotoxicity,Proc. Soc. Exp. Biol. Med. 193, 143–148 (1990).
- M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky, Supplementation with selenium and human immune cell functions. I. Effect on lymphocyte proliferation and interleukin 2 receptor expression,Biol. Trace Elem. Res. 41, 103–114 (1994). CrossRef
- L. Kiremidjian-Schumacher, M. Roy, H. I. Wishe, M. W. Cohen, and G. Stotzky, Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells,Biol. Trace Elem. Res. 41, 115–127 (1994).
- M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky, Effect of selenium on the expression of high affinity interleukin 2 receptors,Proc. Soc. Exp. Biol. Med. 200, 36–43 (1992).
- M. Roy, L. Kiremidjian-Schumacher, H. I. Wishe, M. W. Cohen, and G. Stotzky, Selenium supplementation enhances the expression of interleukin 2 receptor subunits and internalization of interleukin 2,Proc. Soc. Exp. Biol. Med. 202, 295–301 (1993).
- J. E. Spallholz, G. F. Collins, and K. A. Schwartz, A single-test-tube method for the fluorometric determination of selenium,Bioinog. Chem. 9, 453–459 (1978). CrossRef
- M. H. Julius, E. Simpson, and L. A. Herzenberg, A rapid method for the isolation of functional thymus derived murine lymphocytes,Eur. J. Immunol. 3, 645–649 (1973). CrossRef
- M. G. Roncarolo, M. Bigler, J. B. Haanen, H. Yssel, R. Bacchetta, J. E. de Vries, and H. Spits, Natural killer cell clones can effectively process and present protein antigens,J. Immunol. 147, 781–787 (1991).
- Y. Gunji, N. L. Vujanovic, J. C. Hiserodt, R. B. Herberman, and E. Gorelik, Generation and characterization of putified adherent lymphokine-activated killer cells in mice,J. Immunol. 142, 1748–1754 (1989).
- P. D. Brown and F. V. Sepulveda, A rabbit jejunal isolated enterocyte preparation suitable for transport studies,J. Physiol. 363, 257–270 (1985).
- L. D. Koller, J. H. Exson, P. A. Talcott, C. A. Osborne, and G. M. Henningsen, Immune responses in rats supplemented with selenium,Clin. Exp. Immunol. 63, 570–576 (1986).
- C. A. Biron, H. A. Young, and M. T. Kasaian, Interleukin 2-induced proliferation of murine natural killer cells in vivo,J. Exp. Med. 71, 173–188 (1990). CrossRef
- M. J. Robertson and J. Ritz, Role of IL-2 receptors in NK cell activation and proliferation, inNK Cell Mediated Cytotoxicity: Receptors, Signaling, and Mechanisms. E. Lotzova and R. Herberman, eds., CRC, Boca Raton, FL, pp. 183–206 (1992).
- M. J. Robertson, M. A. Caligiuri, T. J. Manley, H. Levine, and J. Ritz, Human natural killer cell adhesion molecules Differential expression after activation and participation in cytolysis.J. Immunol. 145, 3194–3201 (1990).
- T. Timonen, C. G. Gahmberg, and M. Patarroyo, Participation of CD11a-c/CD18, CD2, and RGD-binding receptors in endogenous and interleukin 2-stimulated NK activity of CD3-negative large granular lymphocytes,Int. J. Cancer 46, 1035–1040 (1990). CrossRef
- J. D. Bonnema, K. A. Rivlin, A. T. Ting, R. A. Schoon, R. T. Abraham, and P. J. Leibson, Cytokine-enhanced NK cell-mediated cytotoxicity. Positive modilatory effect of Il-2 and Il-12 on stimulus-dependent granule exocytosis,J. Immunol. 152, 2098–2103 (1994).
- K. A. Smith and D. A. Cantrell, Interleukin-2 regulates its own receptors,Proc. Natl. Acad. Sci. USA 82, 864–868 (1985). CrossRef
- K. A. Smith, Interleukin-2: Inception, impact, and implications,Science 240, 1169–1176 (1988). CrossRef
- P. V. Nash and A. M. Mastro, Activation of primary lymphocytes requires prolonged lectin stimulation,J. Leuk. Biol. 53, 73–78 (1993).
- N. S. Gutgsell and T. R. Malek, Formation of high affinity IL-2 receptors is dependent on a nonligand binding region of the α subunit,J. Immunol. 153, 3899–3907 (1994).
- Y. Minami, T. Kono, T. Miyazaki, and Taniguchi, The Il-2 receptor complex: Its structure, function, and target genes,Annu. Rev. Immunol. 11, 245–267 (1993). CrossRef
- M. A. Caligiuri, A. Zmuidzinas, T. J. Manley, H. Levine, K. A. Smith, and J. Ritz, Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.J. Exp. Med. 171, 1509–1526 (1990). CrossRef
- D. Vitolo, N. L. Vujanovic, H. Rabinowich, M. Schlesinger, R. B. Herberman, and T. L. Whiteside, Rapid Il-2-induced adherence of human natural killer cells. Expression of mRNA for cytokines and IL-2 receptors in adherent NK cells,J. Immunol. 151, 1926–1937 (1993).
- W. H. Chambers, A. B. DeLeo, N. L. Vujanovic, and J. C. Hiserodt, Role of the interleukin-2 receptor in the growth and regulation of LAK activity, inInterleukin-2 and Killer Cells in Cancer, E. Lotzova and R. B. Herberman, eds. CRC, Boca Raton, FL, pp. 339–361 (1990).
- O. de la Calle-Martin, J. Alberola-Ila, P. Engel, J. L. Ingles, V. Fabregat, J. J. Barcelo, F. Lozano, and T. Gallard, Impaired post-transcriptional expression of interleukin-2 receptor in pokeweed mitogen-activated T cells,Eur. J. Immunol. 22, 897–902 (1992). CrossRef
- A. D. Weinberg and S. L. Swain, IL-2 receptor (TAC antigen) protein expression is down-regulated by the 5′-untranslated region of the mRNA,J. Immunol. 144, 4712–4720 (1990).
- T. C. Stadtman, Selenium biochemistry,Annu. Rev. Biochem. 59, 111–127 (1990). CrossRef
- M. J. Berry, L. Banu, and R. Laresen, Type I iodothyronine deiodinase is a selenocysteine-containing enzyme,Nature 349, 438–440 (1991). CrossRef
- M. J. Christensen and K. W. Burgener, Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver,Am. Inst. Nutr. 122, 1620–1626 (1992).
- Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells
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