Research Papers

International Journal of Pancreatology

, Volume 3, Issue 6, pp 497-502

First online:

Exocrine pancreatic secretion in the elderly

  • B. VellasAffiliated withService de Medecine Geriatrique, CHU de Purpan
  • , D. BalasAffiliated withUnité INSERM 151, Bat L3, CHU de Rangueil
  • , J. MoreauAffiliated withService des Maladies de l'Appareil Digestif, CHU de Rangueil
  • , M. BouissonAffiliated withUnité INSERM 151, Bat L3, CHU de Rangueil
  • , F. Senegas-BalasAffiliated withUnité INSERM 151, Bat L3, CHU de Rangueil
  • , M. GuidetAffiliated withUnité INSERM 151, Bat L3, CHU de Rangueil
  • , A. RibetAffiliated withUnité INSERM 151, Bat L3, CHU de Rangueil

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

In order to evaluate impairment of exocrine pancreatic function during aging, 27 subjects (mean age: 36 years±7.8) and 28 subjects (mean age: 72 years±3.2), with no clinical or radiological evidence of digestive disease, were selected. Duodenal aspirates over a 60 min period were obtained during continuous IV infusion of secretin (0.5 U/kg/h) and caerulein (75 ng/kg/h). Bicarbonate, lipase, chymotrypsin, amylase concentrations and output were measured. Bicarbonate, lipase, chymotrypsin concentrations in the aged group were significantly reduced by 17%, 15% and 23% respectively (P<0.05) as compared with those in the young group. In addition, a significant reduction of approximately 45% in bicarbonate and enzyme output levels was observed. This study provides strong evidence for a marked functional involution of the exocrine pancreatic secretion during aging. The potential consequences of this phenomenon on the nutritional status in the elderly are discussed.

Key words

Aging Human pancreas Functional pancreatic tests Lipase Amylase Chymotrypsin Bicarbonate