Immunologic Research

, Volume 18, Issue 1, pp 27–39

Immune cell signaling aberrations in human lupus

  • Stamatis-Nick C. Liossis
  • Petros P. Sfikakis
  • George C. Tsokos
Article

DOI: 10.1007/BF02786511

Cite this article as:
Liossis, SN.C., Sfikakis, P.P. & Tsokos, G.C. Immunol Res (1998) 18: 27. doi:10.1007/BF02786511

Abstract

A large array of heterogeneous aberrations of the immune system have been described in systemic lupus erythematosus (SLE). Since the function and the fate of the immune system cells are governed principally by the biochemical events that follow ligation of specialized cell-surface receptors, we will review in this article recent developments in our understanding of abnormalities in the biochemistry of signals generated either by the antigen-receptor complex or by systems of costimulatory cell-surface molecules, like the CD28/CTLA4:CD80/CD86 and the CD40:CD40L pairs found on the surface membrane of lupus immune cells.

Key Words

Systemic lupus erythematosus Human autoimmunity Lymphocytes Signal transduction Antigen receptor Costimulation 

Copyright information

© Humana Press Inc. 1998

Authors and Affiliations

  • Stamatis-Nick C. Liossis
    • 1
  • Petros P. Sfikakis
    • 2
  • George C. Tsokos
    • 1
    • 3
  1. 1.Department of MedicineUniformed Services University of the Health SciencesBethesda
  2. 2.First Department of Propaedeutic MedicineAthens University Medical SchoolAthensGreece
  3. 3.Department of Clinical PhysiologyWalter Reed Army Institute of ResearchWashington, DC

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