, Volume 19, Issue 2-3, pp 183-190

Regulation of inducible gene expression by the transcription factor NF-κB

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Abstract

The transcription factor NF-κB plays a critical role in regulating inducible gene expression in immune responses. The activation of NF-κB is regulated at multiple levels, probably reflecting a need to maintain a tight control of its activity. We have recently discovered that direct phosphorylation of NF-κB itself is essential for its transcriptional activity and that phosphorylation acts as a switch to determine association of nuclear NF-κB with histone acetylases vs deacetylases.