Immunologic Research

, Volume 19, Issue 2, pp 183–190

Regulation of inducible gene expression by the transcription factor NF-κB

Article

DOI: 10.1007/BF02786486

Cite this article as:
Ghosh, S. Immunol Res (1999) 19: 183. doi:10.1007/BF02786486

Abstract

The transcription factor NF-κB plays a critical role in regulating inducible gene expression in immune responses. The activation of NF-κB is regulated at multiple levels, probably reflecting a need to maintain a tight control of its activity. We have recently discovered that direct phosphorylation of NF-κB itself is essential for its transcriptional activity and that phosphorylation acts as a switch to determine association of nuclear NF-κB with histone acetylases vs deacetylases.

Key Words

NF-κBGene expressionPhosphorylationHistone deacetylationCBP/p300

Copyright information

© Humana Press Inc. 1999

Authors and Affiliations

  1. 1.Section of Immunobiology, Howard Hughes Medical InstituteYale University School of MedicineNew Haven
  2. 2.Yale University School of MedicineNew Haven