Immunologic Research

, Volume 19, Issue 2, pp 107–118

The role of self-recognition in receptor repertoire development


DOI: 10.1007/BF02786480

Cite this article as:
Janeway, C.A. Immunol Res (1999) 19: 107. doi:10.1007/BF02786480


The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on selfpeptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.


Self-recognitionT cell receptorB cell receptorReceptor repertoireIdiotypeAutoimmune diseaseInnate immunity

Copyright information

© Humana Press Inc. 1999

Authors and Affiliations

  1. 1.Section of ImmunobiologyYale University School of Medicine, and The Howard Hughes Medical InstituteNew Haven