The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
Received: 18 July 1995 Accepted: 20 November 1995 DOI:
10.1007/BF02785304 Cite this article as: Hu, Y., Chen, Y., Zhang, Y. et al. Biol Trace Elem Res (1997) 56: 331. doi:10.1007/BF02785304 Abstract
The effect of selenium (Se) in reducing the toxicity of cisplatin in cancer patients was studied. Forty-one patients were randomized into group A (20 patients with Se administration in first cycle of chemotherapy as study cases and without Se in second cycle of chemotherapy as control) and group B (21 patients without Se in first cycle of chemotherapy and with Se in second cycle of chemotherapy). The 400 μg per day of Se as Seleno-Kappacarrageenan were administered from 4 before to 4 d after chemotherapy for study cases. The serum Se increased from 70.4±22.86 to 157.04±60.23 ng/mL (
P<0.001) in patients received Se. The cisplatin dosage was iv administration in 60–80 mg/m 2 on the first day. The results showed that the peripheral WBC counts on day 14 after initiation of chemotherapy in study cases was significantly higher than the controls (3.35±2.01 vs 2.31±1.38 [×10 9L])/L, p<0.05). On the other hand, the consumption of GCSF for the cases was significantly less than the controls (110.1±82.2 vs 723.6±192.6 IU, p<0.05). The volumes of blood transfusion for the study group were also significantly less than the controls (0 vs 62±38mL, p<0.05). The nephrotoxicity of cisplatin was measured by urine enzymes (NAG, GGT, AAP, LAP, and ALP) were determined prior to and at 2, 24, 48, and 72h after initiation of chemotherapy. The urine enzymes NAG, GGT, AAP, and ALP after chemotherapy for cases were significantly lower than the controls. No toxicity of Seleno-Kappacarrageenan was noted. The above results suggest that the Se can be used as an agent for reducing the nephrotoxicity and bone marrow suppression induced by cisplatin. Index Entries Selenium (Seleno-Kappacarrageenan) Cisplatin toxicity (nephrotoxicity, bone marrow suppression), cancer patients References
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