Biological Trace Element Research

, Volume 33, Issue 1, pp 145–150

Lymphocyte glutathione peroxidase activity during exacerbations in multiple sclerosis

  • Per Schmidt Sørensen
  • Jens C. Hansen
  • Jesper Mai
  • Lene R. Nielsen
  • Troels Sørensen
Article

DOI: 10.1007/BF02784003

Cite this article as:
Sørensen, P.S., Hansen, J.C., Mai, J. et al. Biol Trace Elem Res (1992) 33: 145. doi:10.1007/BF02784003

Abstract

Glutathione peroxidase, one of the major antioxidants in the human brain, has been found to have decreased activity in patients suffering from multiple sclerosis (MS). This study compares the activity of lymphocyte glutathione peroxidase (L-GSH-px) in MS patients suffering from acute relapses with clinically stable MS patients and with control patients referred with nondemyelinating neurological diseases. All three groups showed an increase of mean enzymatic activity (MEA) during the observation period. The highest MEA in this study was observed in the MS groups. However, there were no significant differences in the L-GSH-px activity in the three groups. These results are not in accordance with previous investigations, and the need for further research in this field is emphasized.

Index Entries

Multiple sclerosis MS attacks glutathione peroxidase selenium 

Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Per Schmidt Sørensen
    • 1
  • Jens C. Hansen
    • 2
  • Jesper Mai
    • 3
  • Lene R. Nielsen
    • 1
  • Troels Sørensen
    • 1
  1. 1.Department of NeurologyCentral HospitalViborgDenmark
  2. 2.Institute of Environmental and Occupational MedicineUniversity of AarhusAarhusDenmark
  3. 3.Department of NeurologyAarhus University HospitalAarhusDenmark