Prevention by sodium 4,5-dihydroxybenzene1,3-disulfonate (tiron) of vanadium-induced behavioral toxicity in rats
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Recent studies have shown that oral vanadate (V5+) administration results in behavioral toxicity in rats. The chelating agent Tiron (sodium 4,5-dihydroxybenzene-l,3-disulfonate) is an effective antidote in the removal of vanadium from vanadium-loaded rats. In this study, the protective activity of Tiron on vanadate-induced behavioral toxicity was evaluated in adult rats. Intraperitoneal treatment with Tiron at 235 or 470 mg/kg was initiated after 6 wk of oral sodium metavanadate administration (16 mg/kg/d) and continued for 2 wk. Although vanadate exposure did not result in a significant reduction in the general activity of the animals in an open field, a lower active avoidance acquisition could be observed. However, the vanadate-induced behavioral deficit was reverted by Tiron administration at 470 mg/kg. The present results suggest that Tiron may protect, at least in part, against metavanadate-induced behavioral toxicity.
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- Prevention by sodium 4,5-dihydroxybenzene1,3-disulfonate (tiron) of vanadium-induced behavioral toxicity in rats
Biological Trace Element Research
Volume 69, Issue 3 , pp 249-259
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press
- Additional Links
- Sodium metavanadate
- open field
- active avoidance
- Industry Sectors
- Author Affiliations
- 1. Laboratory of Toxicology and Environmental Health, School of Medicine, “Rouira i Virgili” University, San Lorenzo 21, 43201, Reus
- 2. Psychobiology Unit, “Rovira i Virgili” University, 43007, Tarragona, Spain