Biological Trace Element Research

, Volume 59, Issue 1, pp 187–193

Effect of selenium supplementation on mice infected with LP-BM5 MuLV, a murine AIDS model

  • Chumyimg Chen
  • Jinyan Zhou
  • Huibi Xu
  • Yam Jiang
  • Guanfu Zhu
Original Articles

DOI: 10.1007/BF02783244

Cite this article as:
Chen, C., Zhou, J., Xu, H. et al. Biol Trace Elem Res (1997) 59: 187. doi:10.1007/BF02783244

Abstract

LP-BM5 Murine leukemia virus (MuLV) infection of C57BL/6 mice develop a disease that has many features in common with human acquired immunodeficiency syndrome (AIDS), in particular abnormal lymphoproliferation and severe immunodeficiency. Thus, this MAIDS model may be useful for evaluation of potent antirival agents in vivo. Deficiency in antioxidant micronutients such as selenium, zinc, and glutathione have been observed in AIDs and AIDS-related complex (ARC) patients. In the present study, the MAIDS model was used to evaluate immunological and oxidative effect of Se as sodium selenite. Results indicated that Se treatment 0.1 mg/kg/d (p.o.) inhibited splenomegaly and sera IgG elevation effectively. In addition to abnormal immunity, oxidative imbalance possibly existed in MAIDS model, as lipid peroxide increased significantly in spleen and whole blood glutathione peroxidase (GSH-Px) activity decreased markedly. Se supplementation had good protective effect.

Index Entries

Selenium supplementationLP-BM5 MuLVMAIDSoxidative stress

Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • Chumyimg Chen
    • 1
  • Jinyan Zhou
    • 1
  • Huibi Xu
    • 1
  • Yam Jiang
    • 2
  • Guanfu Zhu
    • 2
  1. 1.Department of ChemistryHuazhong University of Science and TechnologyWuhanPROC
  2. 2.Institute of MicrobiologyChinese Academy of Military Medical ScienceBeijingPROC