Biological Trace Element Research

, Volume 59, Issue 1, pp 133–143

Alterations in lipid composition and neuronal injury in primates following chronic aluminium exposure

Authors

  • Sanjay Sarin
    • Department of BiochemistryPostgraduate Institute of Medical Education and Research
  • Vandana Gupta
    • Department of BiochemistryPostgraduate Institute of Medical Education and Research
  • Kiran Dip Gill
    • Department of BiochemistryPostgraduate Institute of Medical Education and Research
Original Articles

DOI: 10.1007/BF02783238

Cite this article as:
Sarin, S., Gupta, V. & Gill, K.D. Biol Trace Elem Res (1997) 59: 133. doi:10.1007/BF02783238

Abstract

The effect of chronic aluminium exposure (25 mg/kg b.wt.) was studied on the lipid composition and various membrane-bound enzymes in different regions of monkey brain. Aluminium (Al) administration caused a significant decrease in the total lipid, glycolipid, and phospholipid content of primate brain. Cholesterol levels and the phospholipid to cholesterol ratio were, however, markedly increased as a consequence of Al administration, thereby indicating a loss of membrane integrity. This was further confirmed when Al treatment was found to have a significant effect on the various membrane-bound enzymes in terms of decreased activities of Na+ K+ ATPase and acetylcholinesterase along with a decrease in the activity of the myelin-specific enzyme, 2′ 3′-cyclic nucleotide phosphohydrolase.

Index Entries

Aluminiumbrainlipidsmembranemonkey

Copyright information

© Humana Press Inc. 1997