, Volume 59, Issue 1-3, pp 133-143

Alterations in lipid composition and neuronal injury in primates following chronic aluminium exposure

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Abstract

The effect of chronic aluminium exposure (25 mg/kg b.wt.) was studied on the lipid composition and various membrane-bound enzymes in different regions of monkey brain. Aluminium (Al) administration caused a significant decrease in the total lipid, glycolipid, and phospholipid content of primate brain. Cholesterol levels and the phospholipid to cholesterol ratio were, however, markedly increased as a consequence of Al administration, thereby indicating a loss of membrane integrity. This was further confirmed when Al treatment was found to have a significant effect on the various membrane-bound enzymes in terms of decreased activities of Na+ K+ ATPase and acetylcholinesterase along with a decrease in the activity of the myelin-specific enzyme, 2′ 3′-cyclic nucleotide phosphohydrolase.