Article

Biological Trace Element Research

, Volume 63, Issue 2, pp 167-175

First online:

Age-dependent changes in metallothionein levels in liver and kidney of the Japanese

  • Minoru YoshidaAffiliated withDepartment of Chemistry, St. Marianna University School of Medicine
  • , Hisayoshi OhtaAffiliated withDepartment of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University
  • , Youji YamaguchiAffiliated withDepartment of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University
  • , Yukio SekiAffiliated withDepartment of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University
  • , Morihisa SagiAffiliated withDepartment of Legal Medicine, St. Marianna University School of Medicine
  • , Kentarou YamazakiAffiliated withDepartment of Legal Medicine, St. Marianna University School of Medicine
  • , Yawara SumiAffiliated withDepartment of Chemistry, St. Marianna University School of Medicine

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Abstract

Samples of liver, renal cortex, and medulla were obtained from 55 forensic autopsies (0- to 95-yr-old Japanese). Metallothionein (MT) was determined by the Ag-hem or Cd-hem method. Zinc (Zn), copper (Cu), and cadmium (Cd) were determined by atomic absorption spectrophotometry. The mean levels of MT were 250 μg/g in the liver, and 394 μg/g (cortex) and 191 μg/g (medulla) in the kidney. Age-dependent changes were observed in both the liver and kidney. In the liver, MT level decreased during infancy and increased thereafter with age. Similar age-dependent changes in the levels of Zn and Cu were observed. In the kidney cortex, MT level increased with age, although no correlation was found after middle age. The levels of Cd and Zn also increased with age until middle age; however, they decreased thereafter. These results suggest that age-dependent changes in renal MT levels are associated with accumulation of Cd.

Index Entries

Metallothionein cadmium zinc copper liver kidney human Japanese