Age-dependent changes in metallothionein levels in liver and kidney of the Japanese
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Samples of liver, renal cortex, and medulla were obtained from 55 forensic autopsies (0- to 95-yr-old Japanese). Metallothionein (MT) was determined by the Ag-hem or Cd-hem method. Zinc (Zn), copper (Cu), and cadmium (Cd) were determined by atomic absorption spectrophotometry. The mean levels of MT were 250 μg/g in the liver, and 394 μg/g (cortex) and 191 μg/g (medulla) in the kidney. Age-dependent changes were observed in both the liver and kidney. In the liver, MT level decreased during infancy and increased thereafter with age. Similar age-dependent changes in the levels of Zn and Cu were observed. In the kidney cortex, MT level increased with age, although no correlation was found after middle age. The levels of Cd and Zn also increased with age until middle age; however, they decreased thereafter. These results suggest that age-dependent changes in renal MT levels are associated with accumulation of Cd.
H. Yoshikawa, Preventive effect of pre-treatment with low dose of metals on the acute toxicity of metals in mice,Ind. Health 8, 184–191 (1970).CrossRef
S. H. Oh, J. T. Deagen, P. P. Whanger and P. H. Wesig, Biological function of metallothionein. V. Its induction in rats by various stresses.Am. J. Physiol. 234, E282-E285 (1978).PubMed
J. R. Riordan and V. Richards, Human fetal liver contains both zinc and copper-rich forms of metallothionein.J. Biol. Chem. 255, 5380–5383 (1980).PubMed
L. Friberg, M. Piscator, G. Nordberg and T. Kjellstrom, inCadmium in the Environment, 2nd ed., L. Friberg, M. Piscator, G. Nordberg, and T. Kjellstrom, eds., CRC, Cleveland, OH, pp. 59–65 (1974).
G. A. Drasch, E. Kretschmer, P. Neidlinger and K. H. Summer, Metallothionein in human liver and kidney: relationship to age, sex, diseases and tobacco and alcohol use.J. Trace Element Electrolytes Health Dis. 2, 233–237 (1988).
S. Onosak and M. G. Cherian, Comparison of metallothionein determination by polarographic and cadmium saturation methods.Toxicol. Appl. Pharmacol.,63, 270–274 (1982).CrossRef
- Age-dependent changes in metallothionein levels in liver and kidney of the Japanese
Biological Trace Element Research
Volume 63, Issue 2 , pp 167-175
- Cover Date
- Print ISSN
- Online ISSN
- Humana Press
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. Department of Chemistry, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
- 2. Department of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University, 1-15-1, Kitasato, 228, Sagamihara, Japan
- 3. Department of Legal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan