Age-dependent changes in metallothionein levels in liver and kidney of the Japanese
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Samples of liver, renal cortex, and medulla were obtained from 55 forensic autopsies (0- to 95-yr-old Japanese). Metallothionein (MT) was determined by the Ag-hem or Cd-hem method. Zinc (Zn), copper (Cu), and cadmium (Cd) were determined by atomic absorption spectrophotometry. The mean levels of MT were 250 μg/g in the liver, and 394 μg/g (cortex) and 191 μg/g (medulla) in the kidney. Age-dependent changes were observed in both the liver and kidney. In the liver, MT level decreased during infancy and increased thereafter with age. Similar age-dependent changes in the levels of Zn and Cu were observed. In the kidney cortex, MT level increased with age, although no correlation was found after middle age. The levels of Cd and Zn also increased with age until middle age; however, they decreased thereafter. These results suggest that age-dependent changes in renal MT levels are associated with accumulation of Cd.
- M. G. Cherian and R. A. Goyer, Metallothioneins and their role in the metabolism and toxicity of metals,Life Sci. 23, 1–10 (1978). CrossRef
- M. Webb, and K. Cain, Function of metallothionein,Biochem. Pharmacol. 31, 137–142 (1982). CrossRef
- H. Yoshikawa, Preventive effect of pre-treatment with low dose of metals on the acute toxicity of metals in mice,Ind. Health 8, 184–191 (1970). CrossRef
- S. H. Oh, J. T. Deagen, P. P. Whanger and P. H. Wesig, Biological function of metallothionein. V. Its induction in rats by various stresses.Am. J. Physiol. 234, E282-E285 (1978).
- A. Bakka and M. Webb, Metabolism of zinc and copper in the neonate: Changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species.Biochem. Pharmacol.,30, 721–725 (1981). CrossRef
- J. R. Riordan and V. Richards, Human fetal liver contains both zinc and copper-rich forms of metallothionein.J. Biol. Chem. 255, 5380–5383 (1980).
- T. Kjellstrom, Exposure and accumulation of cadmium in population from Japan, United States, and Sweden.Environ. Health Perspect. 28, 169–197 (1979). CrossRef
- L. Friberg, M. Piscator, G. Nordberg and T. Kjellstrom, inCadmium in the Environment, 2nd ed., L. Friberg, M. Piscator, G. Nordberg, and T. Kjellstrom, eds., CRC, Cleveland, OH, pp. 59–65 (1974).
- G. A. Drasch, E. Kretschmer, P. Neidlinger and K. H. Summer, Metallothionein in human liver and kidney: relationship to age, sex, diseases and tobacco and alcohol use.J. Trace Element Electrolytes Health Dis. 2, 233–237 (1988).
- S. Onosak and M. G. Cherian, Comparison of metallothionein determination by polarographic and cadmium saturation methods.Toxicol. Appl. Pharmacol.,63, 270–274 (1982). CrossRef
- A. M. Scheuhammer and M. G. Cherian, Quantification of metallothionein by a silver-saturation method.Toxicol. Appl. Pharmacol. 82, 417–425 (1986). CrossRef
- A. H. Zlotkin and M. G. Cherian, Hepatic metallothionein as a source of zinc and cysteine during the first year of life.Pediatr. Res. 24, 326–329 (1988). CrossRef
- J. Chung, N. O. Nartey and M. G. Cherian, Metallothionein levels in liver and kidney of Canadians—a potential indicator of environmental exposure to cadmiumArch. Environ. Health 41, 319–323 (1986). CrossRef
- S. Onosaka, K-S. Min, C. Fukuhara, K. Tanaka, S. Tashiro, I. Shimizu, et al. Concentration of metallothionein and metals in malignant and non-malignant tissues in human liver.Toxicology 38, 261–268 (1986). CrossRef
- Age-dependent changes in metallothionein levels in liver and kidney of the Japanese
Biological Trace Element Research
Volume 63, Issue 2 , pp 167-175
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- 1. Department of Chemistry, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan
- 2. Department of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University, 1-15-1, Kitasato, 228, Sagamihara, Japan
- 3. Department of Legal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511, Kawasaki, Japan