, Volume 7, Issue 1, pp 61–63

Role of IGF-I in muscular atrophy of aging

Symposium on the Assessment of the Growth Hormone/IGF-I Axis in Aging

DOI: 10.1007/BF02778065

Cite this article as:
Borst, S.E. & Lowenthal, D.T. Endocr (1997) 7: 61. doi:10.1007/BF02778065


Loss of muscle mass and strength are well-known consequences of aging. The growth hormone/IGF-I pathway is both impaired with aging and essential for growth and maintenance of skeletal muscle. Despite this, growth hormone (GH) replacement has not been effective in increasing muscle mass and strength in the elderly. Possible explanations for this failure include
  1. 1.

    The presence of other age-related impairments in muscle that prevent the actions of GH and IGF-I and

  2. 2.

    Complications arising from a failure to deliver GH and IGF-I in the physiologically correct manner


This article summarizes the results of clinical trials of GH and IGF-I in the elderly and discusses the current status of strategies for safely and effectively stimulating the GH/IGF-I pathway in this population.

Key Words

Growth hormoneinsulin-like growth factor Iagingsarcopenia

Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  1. 1.Geriatric Research, Education and Clinical CenterVA Medical CenterGainesville
  2. 2.Department of PharmacologyUniversity of FloridaGainesville
  3. 3.Department of MedicineUniversity of FloridaGainesville
  4. 4.Department of Exercise ScienceUniversity of FloridaGainesville