Infection

, Volume 26, Issue 1, pp 16–19

Response to treatment of chronic hepatitis C with interferon α in patients infected with HIV-1 is associated with higher CD4+ cell count

  • S. Mauss
  • H. Klinker
  • A. Ulmer
  • R. Willers
  • B. Weißbrich
  • H. Albrecht
  • D. Häussinger
  • H. Jablonowski
Clinical and Epidemiological Studies Originalia

DOI: 10.1007/BF02768746

Cite this article as:
Mauss, S., Klinker, H., Ulmer, A. et al. Infection (1998) 26: 16. doi:10.1007/BF02768746

Summary

The aim of this study was to assess the efficacy and tolerance of interferon α (IFN α) treatment of chronic hepatitis C in HIV-seropositive patients. Seventeen patients with actively replicating hepatitis C were consecutively enrolled and treated with IFN α 5 MIU three times a week and followed up for at least 6 months after cessation of treatment. Eight patients responded to IFN α therapy with a complete remission of signs of active hepatitis and viral replication (ALT, HCV-RNA) at the end of treatment with IFN α. A sustained complete remission (ALT, HCV-RNA) for at least 6 months after the end of treatment was achieved in five of these eight patients. Complete responders had higher CD4+ cell counts (median 525/μl) compared to non-responders (median 245/μl) (p<0.001). All patients but one completed at least 4 months of treatment. No severe toxicity (> WHO grade 2) due to IFN α treatment occurred. The results indicate that IFN α treatment of chronic hepatitis C in HIV-seropositive patients is successful in a considerable number of cases. Success of treatment with IFN α is related to higher CD4+ cell counts.

Copyright information

© MMV Medizin Verlag GmbH München 1998

Authors and Affiliations

  • S. Mauss
    • 1
  • H. Klinker
    • 3
  • A. Ulmer
    • 4
  • R. Willers
    • 5
  • B. Weißbrich
    • 6
  • H. Albrecht
    • 7
  • D. Häussinger
    • 2
  • H. Jablonowski
    • 2
  1. 1.Kuratorium für ImmunschwächeMünchenGermany
  2. 2.Klinik für Gastroenterologie Hepatologie und InfektiologieUniversität DüsseldorfDüsseldorfGermany
  3. 3.Medizinische KlinikUniversität WürzburgWürzburgGermany
  4. 4.StuttgartGermany
  5. 5.Rechenzentrum Universität DüsseldorfDüsseldorfGermany
  6. 6.Institut für Virologie und ImmunbiologieUniversität WürzburgWürzburgGermany
  7. 7.Medizinische KlinikUniversitäts-Krankenhaus EppendorfHamburgGermany