The Indian Journal of Pediatrics

, Volume 73, Issue 5, pp 409–412

Early onset conjugated hyperbilirubinemia in newborn infants

  • Filiz Tiker
  • Aylin Tarcan
  • Hasan Kilicdag
  • Berkan Gürakan
Original Article

DOI: 10.1007/BF02758562

Cite this article as:
Tiker, F., Tarcan, A., Kilicdag, H. et al. Indian J Pediatr (2006) 73: 409. doi:10.1007/BF02758562

Abstract

Objectives: To determine the causes and related outcomes of early onset conjugated hyperbilirubinemia in a group of newborn infants, and to determine the incidence of sepsis in these neonates.Methods: The charts of 42 babies with conjugated hyperbilirubinemia were retrospectively reviewed.Results: The mean gestational age was 37 weeks, and the mean postnatal age at presentation was 10 days. Culture-proven sepsis was identified in 15 babies (35.7% of total). Gramnegative bacteria were isolated in 10 cases and E. coli was the most common of these agents (7 cases). Perinatal hypoxiaischemia was the second most frequent etiology (7 patients; 16.7% of total). The other diagnoses were blood group incompatibility (n=5), Down syndrome (n=3), cholestasis associated with parenteral nutrition (n=3), neonatal hepatitis (n=2), metabolic liver disease (n=1), biliary atresia (n=1), portal venous thrombosis (n=1), and unknown (n=4). Thirteen babies with sepsis recovered completely with treatment, whereas the prognosis for those with perinatal hypoxia-ischemia was grave (six of seven died).Conclusions: The findings suggest that early onset cholestatic jaundice in newborn infants is more commonly from non-hepatic causes, so it is reasonable to monitor these infants carefully for a period of time before undertaking time-consuming or invasive investigations towards a primary liver disease.

Key words

Cholestasis Conjugated hyperbilirubinemia Newborn Perinatal hypoxia-ischemia and Sepsis 

Copyright information

© Dr.K C Chaudhuri Foundation 2006

Authors and Affiliations

  • Filiz Tiker
    • 1
  • Aylin Tarcan
    • 2
  • Hasan Kilicdag
    • 1
  • Berkan Gürakan
    • 2
  1. 1.Department of PediatricsBaskent University Faculty of Medicine Adana HospitalAdanaTurkey
  2. 2.Baskent University Faculty of Medicine Ankara HospitalAdanaTurkey

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