The Indian Journal of Pediatrics

, Volume 73, Issue 11, pp 975–978

Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures

Original Article

DOI: 10.1007/BF02758299

Cite this article as:
Mittal, P., Manohar, R. & Rawat, A.K. Indian J Pediatr (2006) 73: 975. doi:10.1007/BF02758299

Abstract

Objective

To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures.

Methods

Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg).

Results

Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34±0.90; minute vs 4.61±1.08 minute p<0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25±0.86 minute vs 6.51±1.06 minute p<0.001].

Conclusion

Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.

Key words

Intravenous diazepamIntranasal midazolamProceduresSeizures

Copyright information

© Dr.K C Chaudhuri Foundation 2006

Authors and Affiliations

  1. 1.Department of PediatricsS.S. Medical College and G.M. HospitalRewa