Molecular Neurobiology

, Volume 19, Issue 1, pp 25–41

Angiotensin II type 1 receptor-modulated signaling pathways in neurons

  • Elaine M. Richards
  • Mohan K. Raizada
  • Craig H. Gelband
  • Colin Sumners
Article

DOI: 10.1007/BF02741376

Cite this article as:
Richards, E.M., Raizada, M.K., Gelband, C.H. et al. Mol Neurobiol (1999) 19: 25. doi:10.1007/BF02741376

Abstract

Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasopressin, secretion, effects that involve the modulation of brain noradrenergic pathways. This review focuses on the intracellular events that mediate the functional effects of Ang II in neurons, via AT1 receptors. The signaling pathways involved in shortterm changes in neuronal activity, membrane ionic currents, norepinephrine (NE) release, and longer-term neuromodulatory actions of Ang II, are discussed. It will be apparent from this discussion that the signaling pathways involved in these events, are often distinct.

Index Entries

Angiotensin II type 1 receptorneuronprotein kinase Ccalcium/calmodulinnorepinephrineintracellular signaling

Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  • Elaine M. Richards
    • 1
  • Mohan K. Raizada
    • 1
  • Craig H. Gelband
    • 1
  • Colin Sumners
    • 1
  1. 1.Department of Physiology, College of MedicineUniversity of FloridaGainesville