Molecular Neurobiology

, Volume 10, Issue 2, pp 169–184

Retinoic acid and retinoic acid receptors in development

  • Henry M. Sucov
  • Ronald M. Evans
Proceedings of the Satellite of the 14th ISN Meeting and the First International Workshop entitled The Neuronal Phenotype Molecular Biology, Cell Specification, and Therapeutic Frontiers held in Lozari, Corsica, France, August 19–20, 1993

DOI: 10.1007/BF02740674

Cite this article as:
Sucov, H.M. & Evans, R.M. Mol Neurobiol (1995) 10: 169. doi:10.1007/BF02740674

Abstract

The vitamin A derivative retinoic acid (RA) and related compounds (retinoids) are utilized as signaling molecules in a diverse array of developmental and physiological regulatory processes, including many important in the developing and mature nervous system. Retinoids function by interaction with high affinity receptors of the nuclear receptor family, which also mediate the effects of steroid and thyroid hormones and which act in the nucleus as transcription factors. This review summarizes current knowledge of the molecular mechanisms of retinoid action, the complex role of retinoid receptors in a variety of hormonal signaling processes, and illustrates current efforts to more fully understand the biological functions of retinoid receptors through analysis of downstream gene regulatory networks and studies of mouse gene knockout systems.

Index Entries

Retinoic acidretinoic acid receptorsretinoids

Copyright information

© Humana Press Inc 1995

Authors and Affiliations

  • Henry M. Sucov
    • 1
  • Ronald M. Evans
    • 2
  1. 1.Department of Cell and Neurobiology, Institute for Genetic MedicineUniversity of Southern California School of MedicineLos Angeles
  2. 2.Gene Expression Laboratory, The Howard Hughes Medical InstituteThe Salk Institute for Biological StudiesLa Jolla