Chinese Journal of Clinical Oncology

, Volume 2, Issue 1, pp 505–510

Body mass index (BMI), waist to hip ratio (WHR) and risk of biliary tract cancers: A population —based case—control study in Shanghai, China

  • Xuehong Zhang
  • Yutang Gao
  • Asif Rashid
  • Jie Deng
  • Enju Liu
  • Kai Wu
  • Lu Sun
  • Jiarong Cheng
  • Gloria Gridley
  • Ann Whsing
Original Articles

DOI: 10.1007/BF02739741

Cite this article as:
Zhang, X., Gao, Y., Rashid, A. et al. Chin. J. Clin. Oncol. (2005) 2: 505. doi:10.1007/BF02739741

Abstract

Objective

To investigate the relationship between BMI, WHR andbiliary tract cancers (CBT).

Methods

A population —based case —control study was conducted in urban Shanghai from June 1,1997 to May 31, 2001 involving interviews with 627 new cases of biliary tract cancers aged 35 to 74 years and 959 frequency —matched population controls by gender and age in five —year groups. All subjects were interviewed in person by trained interviewers using a structured questionnaire. An unconditional logistic regression was performed to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Obesity was associated with an increased risk of gallbladder cancer across adulthood at ages 20–29 and 30–39 in females. Compared with subjects in the lowest quartile of WHR, ORs for the highest quartile and P for trend for cancers of gallbladder and extrahepatic bile duct both reached significant levels among males and females.

Conclusion

Our observations in urban Shanghai suggested that obesity in early adult life may contribute to the risk of gallbladder cancer, and increased WHR may substantially elevated risk of cancers of the gallbladder and extrahepatic bile duct.

Keywords

biliary tract cancers body mass index waist to hip ratio case-control study 

Copyright information

© Chinese Anti-Cancer Association and Springer 2003

Authors and Affiliations

  • Xuehong Zhang
    • 1
  • Yutang Gao
    • 1
  • Asif Rashid
    • 2
  • Jie Deng
    • 1
  • Enju Liu
    • 1
  • Kai Wu
    • 1
  • Lu Sun
    • 1
  • Jiarong Cheng
    • 1
  • Gloria Gridley
    • 3
  • Ann Whsing
    • 3
  1. 1.Department of EpidemiologyShanghai Cancer InstituteShanghaiChina
  2. 2.Anderson Cancer CenterUSA
  3. 3.National Cancer InstituteUSA