Journal of Molecular Neuroscience

, Volume 12, Issue 2, pp 111–121

Gangliosides and neutral glycolipids in ependymal, neuronal and primitive neuroectodermal tumors

  • Allan J. Yates
  • Teresa K. Franklin
  • Paula McKinney
  • Raymond Collins
  • Theodore Comas
  • Carl P. Boesel
  • Dennis K. Pearl
Original Articles

DOI: 10.1007/BF02736925

Cite this article as:
Yates, A.J., Franklin, T.K., McKinney, P. et al. J Mol Neurosci (1999) 12: 111. doi:10.1007/BF02736925

Abstract

Neutral glycolipid and ganglioside compositions were determined on 11 ependymal tumors, 12 medulloblastomas, 6 other neuronal tumors of the brain, 4 peripheral neuroblastomas, 1 cerebral primitive neuroectodermal tumor (PNET), and 1 PNET of the thoracic wall. Within the group of tumors that can demonstrate neuronal phenotypes, there was an association between the degree of neuronal differentiation usually demonstrated by these tumors and the proportions of both GD1a and 1b-pathway gangliosides. The amount of globoside also correlated with the amount of 1b pathway gangliosides. Patients with medulloblastomas whose 1b gangliosides made up over 15% of the total gangliosides survived longer that those with lower proportions of 1b gangliosides. The only gangliosides in the choroid plexus papilloma were GM3 and GD1a, but other ependymal tumors had significant amounts of GD1b and its metabolic precursors. Ependymoma and anaplastic ependymoma had similar neutral glycolipid compositions, which were different from subependymoma, which lacked ceramide monohexoside and ceramide dihexoside. These differences in glycolipid compositions suggest that there may be fundamental biological differences between these types of ependymal tumors.

Index Entries

Glycolipidglycosphingolipidgangliosidebrain tumorgliomaprimitive neuroectodermal tumorependymomaneuroblastoma

Abbreviations

CDH

ceramide dihexoside

CMH

ceramide monohexoside

C

chloroform

CTH

ceramide trihexoside

GA1

asialoGM1

HPTLC

high-performance thin-layer chromatography

M

methanol

NGL

neutral glycolipids

PNET

primitive neuroectodermal tumor

TLC

thin-layer chromatography

W

water

Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  • Allan J. Yates
    • 1
  • Teresa K. Franklin
    • 1
  • Paula McKinney
    • 1
  • Raymond Collins
    • 1
  • Theodore Comas
    • 1
  • Carl P. Boesel
    • 1
  • Dennis K. Pearl
    • 2
  1. 1.Department of PathologyThe Ohio State UniversityColumbus
  2. 2.Department of StatisticsThe Ohio State UniversityColumbus