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Gastric motor effects of endothelins in the lower brainstem of the rat

  • Biochemical Pharmacology as an Approach to Gastrointestinal Disorders Section of IUPHAR GI Pharmacology Symposium 12–14 October 1995, Pécs, Hungary
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Abstract

To characterize the modulatory effect of endothelin on brainstem control of gastric motor function, endothelin-1 (ET-1) and endothelin-3 (ET-3) were applied to the surface of the dorsal medulla oblongata in α-chloralose and xylazine anaesthetized, artificially ventilated Sprague-Dawley rats, while intragastric pressure and contractility of the pyloric circular and greater curvature longitudinal muscles as well as blood pressure were monitored. Endothelin-1 and ET-3 equipotently (at the same range of doses) increased intragastric pressure and stimulated contractility of the gastric circular muscle as well as increasing arterial blood pressure. All the gastric effects of endothelins were abolished by bilateral vagotomy at the midcervical level. These results demonstrate that endothelins have vagally mediated gastrointestinal effects in the lower brainstem of the rat and support a role for endothelins in gastrointestinal regulation.

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  1. Department of Pharmacology and Experimental Therapeutics, Louisiana State University Medical Center, 70112, New Orleans, LA, USA

    Z. K. Krowicki & P. J. Hornby

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  1. Z. K. Krowicki
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  2. P. J. Hornby
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Krowicki, Z.K., Hornby, P.J. Gastric motor effects of endothelins in the lower brainstem of the rat. Inflammopharmacol 4, 297–305 (1996). https://doi.org/10.1007/BF02731879

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  • DOI: https://doi.org/10.1007/BF02731879

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