The Indian Journal of Pediatrics

, Volume 65, Issue 4, pp 557–560

Pulse corticosteroid therapy with methylprednisolone or dexamethasone

  • Pankaj Hari
  • Rajendra N. Srivastava
Controversies in Pediatrics

DOI: 10.1007/BF02730894

Cite this article as:
Hari, P. & Srivastava, R.N. Indian J Pediatr (1998) 65: 557. doi:10.1007/BF02730894


Intravenous pulse steroid therapy consists of administration of supraphysiological doses of glucocorticoids. It is useful in conditions where rapid immunosuppression and antiinflammatory effect is desired, as in systemic lupus erythematosus, pemphigus, renal transplantation, steroid resistant nephrotic syndrome and crescentic glomerulonephritis. This therapy may be associated with significant adverse reactions including hypertension, arrhythmias, hypokalemia, psychosis and infections. High dose steroid therapy should therefore be used in selected cases and under careful supervision. The drug most widely used for this treatment is methylprednisolone. However, in view of its easy availability and cost, dexamethasone has been often used in India for the above conditions. While there are no controlled studies comparing the two drugs, it appears that the two drugs may be similar in efficacy. Patients requiring high dose intravenous steroid therapy may be treated effectively with either methylprednisolone or dexamethasone.

Key words

Pulse therapyAdverse reactionsMethylprednisoloneDexamethasone

Copyright information

© Dr. K C Chaudhuri Foundation 1998

Authors and Affiliations

  • Pankaj Hari
    • 1
  • Rajendra N. Srivastava
    • 1
  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew Delhi
  2. 2.Srivastava 487 Mandakini AlakanandaNew Delhi