Somatic Cell and Molecular Genetics

, Volume 23, Issue 3, pp 221–223

Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4

Authors

  • Robin M. Jones
    • Massachusetts General Hospital Cancer Center
    • The Children’s ServiceMassachusetts General Hospital
  • Marcy E. MacDonald
    • Molecular Neurogenetics UnitMassachusetts General Hospital
  • John Branda
    • Massachusetts General Hospital Cancer Center
  • Michael R. Altherr
    • Genomics and Structural Biology GroupLos Alamos National Laboratory
  • David N. Louis
    • Department of PathologyMassachusetts General Hospital
  • Emmett V. Schmidt
    • Massachusetts General Hospital Cancer Center
    • The Children’s ServiceMassachusetts General Hospital
Brief Communication

DOI: 10.1007/BF02721373

Cite this article as:
Jones, R.M., MacDonald, M.E., Branda, J. et al. Somat Cell Mol Genet (1997) 23: 221. doi:10.1007/BF02721373

Abstract

We recently cloned genomic sequences containing the promoter region for the messenger RNA cap binding protein (eIF4E). As the rate-limiting step in translation, eukaryotic initiation factor 4E is important in cellular growth control. Using oligonucleotide primers specific for the promoter region in polymerase chain reactions (PCR), we amplified the human gene in a chromosome 4-specific human/rodent somatic cell panel. This panel mapped single copy genomic sequences for eIF4E in the region 4q21 to 4q25.

Copyright information

© Plenum Publishing Corporation 1997