Bulletin of Materials Science

, Volume 26, Issue 4, pp 415–422

Development of a fully injectable calcium phosphate cement for orthopedic and dental applications

  • Manoj Komath
  • H K Varma

DOI: 10.1007/BF02711186

Cite this article as:
Komath, M. & Varma, H.K. Bull Mater Sci (2003) 26: 415. doi:10.1007/BF02711186


A study on the development of a fully injectable calcium phosphate cement for orthopedic and dental applications is presented. The paper describes its characteristic properties including results of biocompatibility studies.

A conventional two-component calcium phosphate cement formulation (having a powder part containing dry mixture of acidic and basic calcium phosphate particles and a liquid part containing phosphate solution) is modified with a biocompatible gelling agent, to induce flow properties and cohesion. The quantity of the gelling agent is optimized to get a viscous paste, which is smoothly injectable through an 18-gauge needle, with clinically relevant setting parameters.

The new formulation has a setting time of 20 min and a compressive strength of 11 MPa. The X-ray diffraction, Fourier transform infrared spectrometry, and energy dispersive electron microprobe analyses showed the phase to be hydroxyapatite, the basic bone mineral. Scanning electron microscopy revealed a porous structure with particle sizes of a few micrometers. The cement did not show any appreciable dimensional or thermal change during setting. The injectability is estimated by extruding through needle and the cohesive property is assessed by water contact method. The cement passed the in vitro biocompatibility screening (cytotoxicity and haemolysis) tests.


Calcium phosphate cementshydroxyapatitebioceramicsbone substituteorthopedicdental

Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • Manoj Komath
    • 1
  • H K Varma
    • 1
  1. 1.Biomedical Technology WingSree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramIndia