Article

Journal of Biosciences

, Volume 31, Issue 5, pp 575-579

First online:

Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats

  • D. U. OwuAffiliated withDepartment of Physiology, College of Medical Sciences University of Calabar Email author 
  • , A. B. AntaiAffiliated withDepartment of Physiology, College of Medical Sciences University of Calabar
  • , K. H. UdofiaAffiliated withDepartment of Physiology, College of Medical Sciences University of Calabar
  • , A. O. ObembeAffiliated withDepartment of Physiology, College of Medical Sciences University of Calabar
  • , K. O. ObasiAffiliated withDepartment of Physiology, College of Medical Sciences University of Calabar
  • , M. U. EtengAffiliated withDepartment of Biochemistry, College of Medical Sciences University of Calabar

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Abstract

Diabetes mellitus (DM) is a multi-factorial disease which is characterized by hyperglycaemia, lipoprotein abnormalities and oxidative stress. This study evaluated effect of oral vitamin C administration on basal metabolic rate and lipid profile of alloxan-induced diabetic rats. Vitamin C was administered at 200 mg/kg body wt. by gavage for four weeks to diabetic rats after which the resting metabolic rate and plasma lipid profile was determined. The results showed that vitamin C administration significantly (P<0.01) reduced the resting metabolic rate in diabetic rats; and also lowered plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol. These results suggest that the administration of vitamin C in this model of established diabetes mellitus might be beneficial for the restoration of basal metabolic rate and improvement of lipid profile. This may at least in part reduce the risk of cardiovascular events seen in diabetes mellitus.

Keywords

Ascorbic acid diabetes mellitus lipid profile metabolic rate vitamin C