Arbeeny C A, Meysers D S, Bergquist K E and Gregg R E 1992 Inhibition of fatty acid synthesis decreases very-low density lipoprotein secretion in the hamster;J. Lipid Res.
Baird G D, Lomax M A, Symonds H W and Shaw D R 1980 Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cowsin vivo
in relation to lactation and nutrient supply;Biochem. J.
Boillot J, Alamowitch C, Berger A M, Luo J and Bruzzo F 1995 Effect of dietary propionate on hepatic glucose production, whole body glucose utilization, carbohydrate and lipid metabolism in normal rats;Br. J. Nutr.
Buddington K K, Donahoo J B and Buddington R K 2002 Dietary oligofructose and inulin protect mice from enteric and systemic pathogens and tumor inducers;J. Nutr.
Buddington R K, Williams C H, Chen S C and Witherly S A 1996 Dietary supplementation of neosugar alters the feacal flora and decreases activities of some reductive enzymes in human subjects;Am. J. Clin. Nutr.
Campbell J M, Fahey G C and Wolf B W 1997 Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats;.J. Nutr.
Carabin I G and Flamm W G 1999 Evaluation of safety of inulin and oligofructose as dietary fiber;Regul. Toxicol. Pharmacol.
Coudray C, Bellanger J, Castiglia-Delavaud C, Remesy C, Vermorel M and Rayssignuir Y 1997 Effects of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men;Eur. J. Clin. Nutr.
Crittenden R G and Playne M J 1996 Production, properties and applications of food grade oligosaccharides;Trends Food Sci. Technol.
Cummings J H, Macfarlane G T and Englyst H N 2001 Prebiotic digestion and fermentation;Am. J. Clin. Nutr. (Suppl.)
Daubioul C A, Taper H S, De WispelaereL D and Delzenne N M 2000 Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese rats;J. Nutr.
Davignion J and Cohn J S 1996 Triglycerides: a risk factor for coronary heart disease;Atherosclerosis
Debruyn A, Alvarez A P, Sandra P and De Leenheer L 1992 Isolation and identification of β-D-fructofuranosyl-(2,l)-D-fructose, a product of the enzymatic hydrolysis of the inulin fromCichorium intybus.
De Leenheer 1996 Production and use of inulin: industrial reality with a promising future; inCarbohydrates as organic raw materials (eds) H Vanbekkum, H Roper and F Varagen (New York: VCH) Vol. 3, pp 67–92
Delzenne N and Kok N N 1998 Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism;Biochem. Soc. Trans.
Delzenne N and Kok N N 1999 Dietary fructooligosaccharides modify lipid metabolism in the rat;J. Nutr.
Delzenne N, Aertssens J, Verplaetse H, Roccaro M and Roberfroid M 1995 Effect of fermentation fructo oligosaccharides on mineral, nitrogen and energy digestive balance in the rat;Life Sci.
Demigne C, Morand C, Levrat M A, Besson C, Moundras C and Remesey C 1995 Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes;Br. J. Nutr.
Ellegard L, Andersson H and Boseus L 1997 Inulin and oligofructose do not influence the absorption of cholesterol or the excretion of cholesterol, Ca, Mg, Zn, Fe or bile acids but increase energy excretion in ileostomy subjects;Eur. J. Clin Nutr.
Fiordaliso M, Kok N, Desager J P, Goethals F, Deboyser D, Roberfroid M and Delzenne N 1995 Dietary oligofructose lowers serum and VLDL concentrations of triglycerides, phopsholipids and cholesterol in rats;Lipids
Fishbein L, Kaplan H and Gough M 1988 Fructooligosaccharides: a review;Toxicology
Gibbons G F 1990 Assembly and secretion of hepatic very-lowdensity lipoprotein;Biochem. J.
Gibson G R, Beatty E R, Wang X and Cummings J H 1995 Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin;Gastroenterology
Gibson G R and Roberfroid M B 1995 Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics;J. Nutr.
Gibson G R and Wang X 1994 Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture;FEMS Microbiol. Lett.
Gupta A K and Bhatia I S 1980 Glucofructosan biosynthesis inFusarium oxysporum
Gupta A K and Kaur N 1997 Fructan storing plants - A potential source of high fructose syrups;J. Sci. Ind. Res.
Gupta A K and Kaur N (eds) 2000 Fructan metabolism in Jerusalem artichoke and chicory; inCarbohydrate reserves in plants - synthesis and regulation (The Netherlands: Elsevier Science) pp 223–248
Gupta A K, Kaur N and Nath S 1986 Hypocholesterolemic effect ofCichorium intybus roots in plasma and liver of rats;Med. Sci. Res.
Gupta A K, Mamta and Bhatia I S 1985 Glucofructosan metabolism inCichorium intybus
Hendry G 1993 Evolutionary origins and natural functions of fructans. A climatological, biogeographic and mechanistic appraisal;New Phytol.
Hidaka H, Eida T, Takiwaza T, Tokunga T and Tashiro Y 1986 Effects of fructooligosaccharides on intestinal flora and human health;Bifidobac. Microflora
Hidaka H, Tashiro Y and Eida T 1991 Proliferation of bifidobacteria by oligosachharides and their useful effect on human health;Bifidobact. Microflora
Hillgartner F D, Salate L M and Goodridge A G 1995 Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis;Physiol. Rev.
Hond E D, Geypens B and Ghoos Y 2000 Effect of high performance chicory inulin on constipation;Nutr. Res.
Hussein H S, Flickinger E A and Fahey G C 1999 Pet food applications of inulin and oligofructose;J. Nutr. (Suppl.)129 1454–1456
Illman R J, Toppong D L, McIntosh G H, Trimble R P and Storer G B 1988 Hypercholestrolemic effects of dietary propionate: studies in whole animals and perfused rat liver;Ann. Nutr. Metab.
Jackson K G, Taylor G R J, Clohessy A M and Williams C M 1999 The effect of daily intake of inulin on fasting lipid, insulin and glucose concentration in middle-aged men and women;Br. J. Nutr.
Jenkins D J A, Wolever T M S and Jenkins A 1991 Specific types of colonic fermentation may raise low-density-lipoprotein-cholesterol concentrations;Am. J. Clin. Nutr.
Kato I 2000 Antitumour activity of the lactic acid bacteria; inProbiotics (eds) R Fuller and G Perdigon (Dordrecht: Kluwer Academic Publishers) pp 115–138
Kaur N, Gupta A K and Saijpal S 1988 Hypotriglyceridaemic effect ofCichorium intybus roots in ethanol injected and saturated fat-fed rats;Med. Sci. Res.
Kaur N, Gupta A K, Saijpal S, Indu and Gupta P P 1989 Trigylceride and cholesterol lowering effect of chicory roots in the liver of dexamethasone-injected rat;Med. Sci. Res.
Kaur N, Gupta A K and Uberoi S K 1991 Cholesterol lowering effect of chicory (Cichorium intybus) root in caffeine-fed rats;Med. Sci. Res.
Kaur N, Jain H, Mann P, Gupta A K and Singh R 1992 A comparison of properties of invertases and inulinase from chicory;Plant Physiol. Biochem.
Kleessen B, Sykura B, Zunft H J and Blaut M 1997 Effects of inulin and lactose on faecal microflora, microbial activity and bowel habit in elderly constipated persons;Am. J. Clin. Nutr.
Kohwi Y, Imai K, Tamura Z and Hashimoto Y 1978 Antitumour effect of Bifidobacterium infantis in mice;Gann
Kok N N, Roberfroid M, Robert A and Delzenne N 1996 Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats;Br. J. Nutr.
Kulkarni N and Reddy B S 1994 Inhibitory effect ofBifidobacterium longum
cultures on the azoxymethane-induced aberrant crypt loci formation and fecal bacterial b-glucuronidase;Proc. Soc. Exp. Biol. Med.
Lee K U, Park J I, Kim C H, Hong S K and Suh K I 1996 Effect of decreasing plasma free fatty acids by acipimox on hepatic glucose metabolism;Metabolism
Levrat M A, Remesy C and Demigne C 1991 High propionate acid fermentation and mineral accumulation in the caecum adapted to different levels of inulin;J. Nutr.
Levrat M A, Remesy C and Demigne C 1993 Influence of inulin on urea and ammonia in the rat caecum: consequences on nitrogen excretion;J. Nutr. Biochem.
Lopez H W, Coudray C, Levrat M A, Coundray C F, Demigne C and Remesy C 2000 Fructo oligosaccharides enhance mineral apparent absorption and counteract the deleterious effects of phytic acid on mineral homeostasis in rats;J. Nutr. Biochem.
Luk G D and Baylin S B 1984 Ornithine decarboxylase as biological marker in familial colonic polyps;New Engl. J Med.
Luk G D, Zhang S Z and Hamilton S R 1989 Effects of timing of administration and dose of difluoro methyl ornithine on rat colonic carcinogenesis;J. Natl. Cancer Inst.
Luo J, Rizkalla S W, Alamovitch C, Boussairi A and Blayo A 1996 Chronic consumption of short chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism;Am. J. Clin. Nutr.
Lupton J R and Marchand L J 1989 Independent effects of fibre and pectin on colonic luminal ammonia concentration;J. Nutr.
MacGarey J D, Leatherman G F and Foster D W 1978 Carnitine palmitoyl transferase 1. The site of inhibition of hepatic fatty acid oxidation by malonyl CoA;J. Biol. Chem.
Menne E, Guggenbuhl N and Roberfroid M 2000 Fn-type chicory inulin hydrolysate has a prebiotic effect in humans;J. Nutr.
Miller-Catchpole R 1989 Bifidobacteria in clinical microbiology and medicine; inBiochemistry and physiology of bifidobacteria (eds) A Bezkorovainy and R Miller-Catchpole (Boca Raton: CRC Press) pp 177–200
Morgan L M 1996 The metabolic role of G1P: Physiology and pathology;Biochem. Soc. Trans.
Mortensen P B 1992 Effect of oral administered lactulose on colonic nitrogen metabolism and excretion;Hepatology
Mukhopadhay T, Tainsky M, Cavander A C and Roth A C 1991 Specific inhibition of K-ras expression and tumourigenicity of long cancer cells by antisense RNA;Cancer Res.
Ohta A, Ohtsuki M, Takizawa T, Inaba H, Adachi T and Kimura S 1994 Effects of fructooligosaccharides on the absorption of magnesium and calcium by cecectomized rats;Int. J. Vitam. Nutr. Res.
Okawa T, Niibe H, Arai T, Sekiba K, Noda K, Takeuchi S, Hashimoto S and Ogawa N 1993 Effect of LC 9018 combined with radiation therapy on carcinoma of the uterine cervix;Cancer
Oku T, Tokunaga T and Hosoya H 1984 Non-digestibility of a new sweetener, “Neosugars” in the rat;J. Nutr.
Parker S L, Tong T, Bolden S and Wingo C A 1997 Cancer statistics;Cancer J. Clin.
Pazola Z and Cieslak J 1979 Changes in carbohydrates during the production of coffee substitute extracts especially in the roasting processes;Food Chem.
Pegg A E and Dolan M E 1989 Investigation of sequence specificity in DNA alkylation and repair using oligodeoxy ribonucleotide substrate; inDNA repair mechanisms and their biological implications in mammalian cells (eds) M W Lambart and J Laval (New York: Plenum Press) pp 45–59
Porter C W, Herrera-ornelas L, Clark J, Pera P, Petrelli N J and Mittleman A 1987 Polyamine biosynthetic activity in normal and neoplastic human colorectal tissue;Cancer
Reddy B S 1999 Possible mechanisms by which pro-and prebiotics influence colon carcinogenesis and tumour;J. Nutr. (Suppl.)
Reddy B S and Rivenson A 1993 Inhibitory effect ofBifidobacterium longum
on colon, mammary and liver carcinogenesis induced by 2-amino-3-methyl imidazol [4,5-f] quinoline, a food mutagen;Cancer Res.
Remesy C, Behr S R, Levrat M A and Demigne C 1992 Fibre fermentability in the rat caecum and its physiological consequence;Nutr. Rev.
Remesy C, Levrat M A, Gamet L and Demigne C 1993 Faecal fermentation in rats fed oligosachharides (inulin) are modulated by dietary calcium level;Am. J. Physiol.
Roberfroid M B 1993 Dietary fibre, inulin and oligofructose: a review comparing their physiological effects;Crit. Rev. Food Sci. Technol.
Roberfroid M B 2001 Prebiotics: preferential substrates for specific germs?;Am. J. Clin. Nutr. (Suppl.)
Roberfroid M B, Bornet F, Bouley Ch and Cummings J H 1995 Colonic micro flora: nutrition and health;Nutr. Rev.
Rodwell V W, Nordstorn J L and Mitshelen J L 1976 Regulation of HMG CoA reductase;Adv. Lipid Res.
Roland N, Nugon-Baudon L, Raiband P and Szilit O 1993 Comparative study of the fermentative characteristics of inulin and different types of fibre in rats inoculated with a human whole faecal flora;Br. J. Nutr.
Rowland I R, Rumney C J, Coutts J T and Lievense L C 1998 Effect ofBifidobacterium longum
and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats;Carcinogenesis
Rumessen J J, Bode S, Hamberg O and Gudman-Hoyer E 1990 Fructans of jerusalem artichokes: intestinal transport, absorption, fermentation and influence;Am. J. Clin Nutr.
Sekine K, Ohta J, Onishi M, Tatsuki T, Shimokawa Y, Toida T, Kawashima T and Hashimoto Y 1995 Analysis of antitumour properties of effector cells stimulated with a cell wall preparation of Bifidobacterium infants;Biol. Pharm. Bull.
Singh J, Kelloff G and Reddy B S 1992 Effect of chemopreventive agents on intermediate biomarkers during different stages of azoxymethane-induced colon carcinogenesis;Cancer Epidemiol. Biomark. Prev.
Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N and Reddy B S 1997Bifidobacterium longum
, a lactic acidproducing intestinal microflora inhibit colon cancer and modulate the intermediate biomarkers of colon carcinogenesis;Carcinogenesis
Smeekens S, Angenent G, Ebskamp M and Weisbeek P 1991 Molecualr biology of fructan accumulation in plants;Biochem. Soc. Trans.
Stals H K, Top W and Decleercq P E 1994 Regulation of triacylglycerol synthesis in permeabolized rat hepatocytes. Role of fatty acid concentration and diacylglycerol acyl transferase;FEBS Lett.
Sugimura T, Wakabayashi K, Ohgaki H, Takayama S, Nagao M G and Esumi H 1991 Heterocyclic amines produced in cooked food: unavailable zenobiotics; inXenobiotics and cancer (ed.) L Ernster (Tokyo: Japan Scientifc Society Press) pp 279–288
Taguchi A, Ohta A, Abe M, Baba S, Ohtsuki M, Takizawa T, Yuda Y and Adachi T 1994 The influence of fructooligosaccharides on the bone of model rats with ovarectomized osteoporosis;Sci. Rep. Meiji Seika Kaisha
Taper H S, Lemort C and Roberfroid M 1998 Inhibition effect of dietary inulin and oligofructose on growth of transplantable mouse tumour;Anticancer Res.
Taper H S and Roberfroid M 1999 Influence of inulin and oligofructose on breast cancer and tumor growth;J. Nutr. (Suppl.) 129 1488–1491
Tetens I G, Livesey G and Eggum B O 1996 Effect of type and level of dietary fibre supplements on nitrogen retention and excretion patterns;Br. J. Nutr.
Tokunaga T, Oku T and Hosoya N 1986 Influence of chronic intake of a new sweetener fructooligosaccharide (Neosugar) on growth and gastro intestinal function in the rat;J. Nutr. Sci. Vitam.
Trautwein E A, Rieckhoff D and Erbersdobler H F 1998 Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters;J. Nutr.
Van denHeuvel E G H M, Muys T, Van DokkumW and Schaafsma G 1999 Oligofructose stimulates calcium absorption in adolescents;Am. J. Clin. Nutr.
Van Loo J, Coussement P, De Leenheer L, Hoebregs H and Smits G 1995 On the presence of inulin and oligofructose as natural ingredients in western diet;CRC Crit. Rev. Food Sci. Nutr.
Vijin I and Smeekens S 1999 Fructan: more than a reserve carbohydrate?;Plant Physiol.
Wang X and Gibson G R 1993 Effects of thein vitro
fermentation of oligofructose and inulin by bacteria growing in the human large intestine;J. Appl. Bacteriol.
Wargovich M H, Chen D D, Jimenez A, Steele V E, Velasco M, Stephens C, Price R, Gray K and Kelloff G J 1996 Aberrent crypts as a biomarker for colon cancer, evaluation of potential chemopreventive agents in the rat;Cancer Epidemiol. Biomark. Prev.
Weidmann M and Jager M 1997 Synergistic sweeteners;Food Ingredients Int. (November-December) 51–56
Williams C M 1999 Effects of inulin on lipid parameters in humans;J. Nutr.
Yamashita K, Kawai K and Itakura K 1984 Effect of fructooligosaccharides on blood glucose and serum lipids in diabetic subjects;Nutr. Res.
Younes H, Demigne C and Remesy C 1996 Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rats;Br. J. Nutr.
Younes H, Garleb K, Behr S, Remesy C and Demigne C 1995 Fermentable fibres or oligosachharides reduce urinary nitrogen excretion by increasing urea disposal in the rat cecum;J. Nutr.
Younes H, Remesy C, Behr S and Demigne C 1997 Fermentable carbohydrate exerts an urea lowering effect in normal and nephrectomised rats;Am. J. Physiol.