Journal of Chemical Sciences

, Volume 115, Issue 5, pp 373–400

Non-protein amino acids in peptide design

  • S. Aravinda
  • N. Shamala
  • Rituparna S. Roy
  • P Balaram
Article

DOI: 10.1007/BF02708230

Cite this article as:
Aravinda, S., Shamala, N., Roy, R.S. et al. J Chem Sci (2003) 115: 373. doi:10.1007/BF02708230

Abstract

An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.

Keywords

Peptide designcrystal structuresC-H…O hydrogen bondhybrid peptidesD-amino acidsβ-amino acids

Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • S. Aravinda
    • 1
  • N. Shamala
    • 1
  • Rituparna S. Roy
    • 2
  • P Balaram
    • 2
    • 3
  1. 1.Department of PhysicsIndian Institute of ScienceBangaloreIndia
  2. 2.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia
  3. 3.Chemical Biology UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia