Journal of Biosciences

, Volume 30, Issue 1, pp 93–102

Genotype, phenotype and cancer: Role of low penetrance genes and environment in tumour susceptibility

Article

DOI: 10.1007/BF02705154

Cite this article as:
Kotnis, A., Sarin, R. & Mulherkar, R. J Biosci (2005) 30: 93. doi:10.1007/BF02705154

Abstract

Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.

Keywords

Gene-environment interactionslow penetrance genesmultiple primary cancersSNP

Abbreviations used

HNSCC

Head and neck squanous cell carcinoma

MMR

mismatch repair

NAT

N-acetyltransferase

SNP

single nucleotide polymorphism

UADT

upper aero-digestive tract

XME

Xenobiotic metabolizing enzyme

Copyright information

© Indian Academy of Sciences 2005

Authors and Affiliations

  1. 1.Genetic EngineeringACTREC, Tata Memorial CentreNavi MumbaiIndia
  2. 2.Tata Memorial HospitalMumbaiIndia