Journal of Biosciences

, 28:637

An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants

Review

DOI: 10.1007/BF02703339

Cite this article as:
Dubey, V.S., Bhalla, R. & Luthra, R. J Biosci (2003) 28: 637. doi:10.1007/BF02703339

Abstract

Terpenoids are known to have many important biological and physiological functions. Some of them are also known for their pharmaceutical significance. In the late nineties after the discovery of a novel non-mevalonate (non-MVA) pathway, the whole concept of terpenoid biosynthesis has changed. In higher plants, the conventional acetate-mevalonate (Ac-MVA) pathway operates mainly in the cytoplasm and mitochondria and synthesizes sterols, sesquiterpenes and ubiquinones predominantly. The plastidic non-MVA pathway however synthesizes hemi-, mono-, sesqui- and di-terpenes, along with carotenoids and phytol chain of chlorophyll. In this paper, recent developments on terpenoids biosynthesis are reviewed with respect to the non-MVA pathway.

Keywords

Acetate-mevalonateDOXPnon-MVA pathwayplantsterpenoids

Abbreviations used

ATP

adenosine triphosphate

CDP

cytidine diphosphate

CDP-ME

4-diphosphocytidyl-2-C-methyl-D-erythritol

CDP-ME2P

4-diphosphocytidyl-2-C-methyl-D-erythritol-2-phosphate

CTP

cytidine triphosphate

DMAPP

dimethylal-lyl diphosphate

DOXP

1-deoxy-D-xylulose-5-phosphate

DXS

DOXP synthase

DXR

DOXP reductoisomerase

FPP

farnesyl diphosphate

GAP

glyceraldehyde-3-phosphate

GGPP

geranylgeranyl diphosphate

GPP

geranyl diphosphate

HMBPP

1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate

HMG-CoA

3-hydroxy-3-methylglutaryl-CoA

HMGR

3-hydroxy-3-methylglutaryl-CoA reductase

IPP

isopentenyl diphosphate

MECP

2C-methyl-D-erythritol 2, 4-cyclodiphosphate

MEP

2-C-methyl-D-erythritol-4-phosphate

MVA

mevalonate

P

phosphate

PP

diphosphate

TPP

thiamin diphosphate

Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • Vinod Shanker Dubey
    • 1
  • Ritu Bhalla
    • 1
    • 2
  • Rajesh Luthra
    • 1
    • 3
  1. 1.Neurobiotechnology CenterThe Ohio State UniversityColumbusUSA
  2. 2.Plant Microbes Interaction Lab, Department of Biological SciencesNational University of SingaporeSingapore
  3. 3.CSIR ComplexNew DelhiIndia