Journal of Biosciences

, Volume 20, Issue 2, pp 235–243

Prediction of B-cell epitopes forSalmonella typhi OmpC

  • A Arockiasamy
  • S Krishnaswamy
Article

DOI: 10.1007/BF02703271

Cite this article as:
Arockiasamy, A. & Krishnaswamy, S. J Biosci (1995) 20: 235. doi:10.1007/BF02703271

Abstract

The possible B-cell epitopes of the outer membrane porin OmpC ofSalmonella typhi have been identified, using the primary structure of the protein, by means of multiple sequence alignment and the known molecular structure of two other porins. From the analysis, 8 regions were identified as immunodominant and these were ranked based on antigenic index and the ratio of the number of nonconserved residues to the fragment length. Model building of the top two ranked regions show the tendency to form loop structures supporting the possibility of these being candidate epitopes.

Keywords

Epitope identificationcomputer modellingmultiple sequence alignmentSalmonella typhi

Copyright information

© Indian Academy of Sciences 1995

Authors and Affiliations

  • A Arockiasamy
    • 1
  • S Krishnaswamy
    • 1
  1. 1.Bioinformatics Centre, School of BiotechnologyMadurai Kamaraj UniversityMaduraiIndia