Squalene synthase inhibition: A novel target for the management of dyslipidemia
- Cite this article as:
- Davidson, M.H. Curr Atheroscler Rep (2007) 9: 78. doi:10.1007/BF02693932
A new class of compounds, known as squalene synthase inhibitors, has recently reached phase III clinical trials and may provide another therapeutic option for clinicians to improve risk management of low-density lipoprotein cholesterol (LDL-C). The clinical need for another LDL-C-lowering therapy is evident by the inability to achieve an LDL-C target of less than 70 mg/dL in the majority of very high-risk patients on statin monotherapy. Human clinical trial data with TAK-475, a novel and potent inhibitor of squalene synthase, have not yet been published.