Squalene synthase inhibition: A novel target for the management of dyslipidemia
- Michael H. Davidson MD
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A new class of compounds, known as squalene synthase inhibitors, has recently reached phase III clinical trials and may provide another therapeutic option for clinicians to improve risk management of low-density lipoprotein cholesterol (LDL-C). The clinical need for another LDL-C-lowering therapy is evident by the inability to achieve an LDL-C target of less than 70 mg/dL in the majority of very high-risk patients on statin monotherapy. Human clinical trial data with TAK-475, a novel and potent inhibitor of squalene synthase, have not yet been published.
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- Squalene synthase inhibition: A novel target for the management of dyslipidemia
Current Atherosclerosis Reports
Volume 9, Issue 1 , pp 78-80
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- 1. Radiant Research, 515 N. State Street, Suite 2700, 60610, Chicago, IL, USA