Integrative Physiological & Behavioral Science

, Volume 38, Issue 2, pp 133–145

Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats


DOI: 10.1007/BF02688831

Cite this article as:
Parker, L.A. & Mechoulam, R. Integrative Physiological & Behavioral Science (2003) 38: 133. doi:10.1007/BF02688831


Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, Δ-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.

Key words

classical conditioningnauseaemesistaste avoidance learningtaste aversion learningcannabinoidstaste reactivity

Copyright information

© Springer 2003

Authors and Affiliations

  1. 1.Department of PsychologyWilfrid Laurier UniversityWaterloo
  2. 2.School of PharmacyHebrew University Medical FacultyJerusalemIsrael